Panoramic optical mapping reveals continuous epicardial reentry during ventricular fibrillation in the isolated swine heart.

Panoramic optical mapping reveals continuous epicardial reentry during ventricular fibrillation in the isolated swine heart. Research Abstract Details 

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Panoramic optical mapping reveals continuous epicardial reentry during ventricular fibrillation in the isolated swine heart. Abstract Text:

Jack M Rogers,Gregory P Walcott,James D Gladden,Sharon B Melnick,Matthew W Kay,

During ventricular fibrillation (VF), activation waves are fragmented and the heart cannot contract synchronously. It has been proposed that VF waves emanate from stable sources ("mother rotors"). Previously, we used new optical mapping technology to image VF wavefronts from nearly the entire epicardial surface of six isolated swine hearts. We found that VF was not driven by epicardial rotors, but could not exclude the presence of stable rotors hidden within the ventricular walls. Here, we use graph theoretic analysis to show that, in all 17 VF episodes we analyzed, it was always possible to trace sequences of wavefronts through series of fragmentation and collision events from the beginning to the end of the episode. The set of wavefronts that were so related (the dominant component) consisted of 92%+/-1% of epicardial wavefronts. Because each such wavefront sequence constitutes a continuous activation front, this finding shows that complete reentrant pathways were always present on the epicardial surface and therefore, that wavefront infusion from nonepicardial sources was not strictly necessary for VF maintenance. These data suggest that VF in this model is not driven by localized sources; thus, new anti-VF treatments designed to target such sources may be less effective than global interventions.

Panoramic optical mapping reveals continuous epicardial reentry during ventricular fibrillation in the isolated swine heart. Publishing Authors By Initials

JM Rogers,GP Walcott,JD Gladden,SB Melnick,MW Kay,

For similar cardiovascular diseases: heart diseases: arrhythmias, cardiac: ventricular fibrillation research abstracts see: cardiovascular diseases: heart diseases: arrhythmias, cardiac: ventricular fibrillation research

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Panoramic optical mapping reveals continuous epicardial reentry during ventricular fibrillation in the isolated swine heart. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biophysical journal

VOLUME: 92

Page Numbers: 1090-5

Journal Abbreviation: Biophys. J.

ISSN: 0006-3495

DAY: 10

MONTH: 11

YEAR: 2006

Panoramic optical mapping reveals continuous epicardial reentry during ventricular fibrillation in the isolated swine heart. Information

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LANGUAGE: eng

NlmUniqueID: 370626

Panoramic optical mapping reveals continuous epicardial reentry during ventricular fibrillation in the isolated swine heart. Keywords Mesh Terms:

KEYWORDS: Ventricular Fibrillation

MESH TERMS: physiopathology

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Grant and Affiliation Information for Panoramic optical mapping reveals continuous epicardial reentry during ventricular fibrillation in the isolated swine heart.

AFFILIATION: Department of Biomedical Engineering, University of Alabama, Birmingham, Alabama, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL64184

ACRONYM: HL

MEDLINETA: Biophys J

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