Pancreatic stellate cells: partners in crime with pancreatic cancer cells.

Pancreatic stellate cells: partners in crime with pancreatic cancer cells. Research Abstract Details 

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Pancreatic stellate cells: partners in crime with pancreatic cancer cells. Abstract Text:

Alain Vonlaufen,Swapna Joshi,Changfa Qu,Phoebe A Phillips,Zhihong Xu,Nicole R Parker,Cheryl S Toi,Romano C Pirola,Jeremy S Wilson,David Goldstein,Minoti V Apte,Alain Vonlaufen,Swapna Joshi,Changfa Qu,Phoebe A Phillips,Zhihong Xu,Nicole R Parker,Cheryl S Toi,Romano C Pirola,Jeremy S Wilson,David Goldstein,Minoti V Apte,

Pancreatic stellate cells (PSC) produce the stromal reaction in pancreatic cancer, but their role in cancer progression is not fully elucidated. We examined the influence of PSCs on pancreatic cancer growth using (a) an orthotopic model of pancreatic cancer and (b) cultured human PSCs (hPSC) and human pancreatic cancer cell lines MiaPaCa-2 and Panc-1. Athymic mice received an intrapancreatic injection of saline, hPSCs, MiaPaCa-2 cells, or hPSCs + MiaPaCa-2. After 7 weeks, tumor size, metastases, and tumor histology were assessed. In vitro studies assessed the effect of cancer cell secretions on PSC migration and the effect of hPSC secretions on cancer cell proliferation, apoptosis, and migration. Possible mediators of the effects of hPSC secretions on cancer cell proliferation were examined using neutralizing antibodies. Compared with mice receiving MiaPaCa-2 cells alone, mice injected with hPSCs + MiaPaCa-2 exhibited (a) increased tumor size and regional and distant metastasis, (b) fibrotic bands (desmoplasia) containing activated PSCs within tumors, and (c) increased tumor cell numbers. In vitro studies showed that, in the presence of pancreatic cancer cells, PSC migration was significantly increased. Furthermore, hPSC secretions induced the proliferation and migration, but inhibited the apoptosis, of MiaPaCa-2 and Panc-1 cells. The proliferative effect of hPSC secretions on pancreatic cancer cells was inhibited in the presence of neutralizing antibody to platelet-derived growth factor. Our studies indicate a significant interaction between pancreatic cancer cells and stromal cells (PSCs) and imply that pancreatic cancer cells recruit stromal cells to establish an environment that promotes cancer progression.

Pancreatic stellate cells: partners in crime with pancreatic cancer cells. Publishing Authors By Initials

A Vonlaufen,S Joshi,C Qu,PA Phillips,Z Xu,NR Parker,CS Toi,RC Pirola,JS Wilson,D Goldstein,MV Apte,A Vonlaufen,S Joshi,C Qu,PA Phillips,Z Xu,NR Parker,CS Toi,RC Pirola,JS Wilson,D Goldstein,MV Apte,

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Pancreatic stellate cells: partners in crime with pancreatic cancer cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cancer research

VOLUME: 68

Page Numbers: 2085-93

Journal Abbreviation: Cancer Res.

ISSN: 1538-7445

DAY: 1

MONTH: Apr

YEAR: 2008

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LANGUAGE: eng

NlmUniqueID: 2984705

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Grant and Affiliation Information for Pancreatic stellate cells: partners in crime with pancreatic cancer cells.

AFFILIATION: Pancreatic Research Group, South Western Sydney Clinical School, The University of New South Wales, Sydney, New South Wales 2052, Australia.

Country: United States

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MEDLINETA: Cancer Res

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