Pancreatic islet expression studies and polymorphic DNA markers in the genes encoding hepatocyte nuclear factor-3alpha, -3beta, -3gamma, -4gamma, and -6.

Pancreatic islet expression studies and polymorphic DNA markers in the genes encoding hepatocyte nuclear factor-3alpha, -3beta, -3gamma, -4gamma, and -6. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Pancreatic islet expression studies and polymorphic DNA markers in the genes encoding hepatocyte nuclear factor-3alpha, -3beta, -3gamma, -4gamma, and -6. Abstract Text:

The genes encoding the functionally related hepatocyte nuclear factors HNF-1alpha and HNF-4alpha play a critical role in normal pancreatic beta-cell function. Mutations in these liver-enriched transcription factors result in two forms of early-onset type 2 diabetes (maturity-onset diabetes of the young [MODY]), MODY3 and MODY1, which are characterized by impaired glucose-stimulated insulin secretion, early disease onset, and autosomal dominant inheritance. The transcriptional hierarchy of HNFs suggests that other proteins of the regulatory cascade might be responsible for other forms of MODY and/or late-onset type 2 diabetes. In this study, we show that HNF-3alpha, -3beta, -3gamma, -4gamma, and -6 are expressed in pancreatic beta-cells. We report the identification and characterization of simple tandem repeat DNA polymorphisms in the genes encoding HNF-3alpha, -3beta, -3gamma, -4gamma, and -6 and the mapping of HNF-6 to chromosome bands 15q21.1-21.2 by fluorescence in situ hybridization. These markers will be useful to study the role of genetic variation in these genes in the pathogenesis of type 2 diabetes.

Pancreatic islet expression studies and polymorphic DNA markers in the genes encoding hepatocyte nuclear factor-3alpha, -3beta, -3gamma, -4gamma, and -6. Publishing Authors By Initials

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

PUBMED ID PMID:

MEDLINE DATE:

Pancreatic islet expression studies and polymorphic DNA markers in the genes encoding hepatocyte nuclear factor-3alpha, -3beta, -3gamma, -4gamma, and -6. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Diabetes

VOLUME: 46

Page Numbers: 1364-7

Journal Abbreviation: Diabetes

ISSN: 0012-1797

DAY: 14

MONTH: Aug

YEAR: 1997

Pancreatic islet expression studies and polymorphic DNA markers in the genes encoding hepatocyte nuclear factor-3alpha, -3beta, -3gamma, -4gamma, and -6. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372763

Pancreatic islet expression studies and polymorphic DNA markers in the genes encoding hepatocyte nuclear factor-3alpha, -3beta, -3gamma, -4gamma, and -6. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: genetics

Chemical & Substance for Abstract: Pancreatic islet expression studies and polymorphic DNA markers in the genes encoding hepatocyte nuclear factor-3alpha, -3beta, -3gamma, -4gamma, and -6. Information

Substance Name: Hepatocyte Nuclear Factor 1-beta

Registry Number: 138674-15-4

Grant and Affiliation Information for Pancreatic islet expression studies and polymorphic DNA markers in the genes encoding hepatocyte nuclear factor-3alpha, -3beta, -3gamma, -4gamma, and -6.

AFFILIATION: Laboratory of Metabolic Diseases, Rockefeller University, New York, New York 10021, USA.

Country: UNITED STATES

AGENCY: United States NCI

GRANT: CA40046

ACRONYM: CA

MEDLINETA: Diabetes

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER: AF009423

Number Hits: 0

Pancreatic islet expression studies and polymorphic DNA markers in the genes encoding hepatocyte nuclear factor-3alpha, -3beta, -3gamma, -4gamma, and -6 Related Publications

• A biomechanical comparison of scaphoid fixation with bone grafting using iliac bone or distal radius bone.
• Assessment by electron-microscopy of recombinant Vibrio cholerae and Salmonella vaccine strains expressing enterotoxigenic Escherichia coli-specific surface antigens.
• Dissecting the transcriptional network of pancreatic islets during development and differentiation.
• Distribution of lactate dehydrogenase in healthy and degenerative canine stifle joint cartilage.
• Domain analysis of lipoprotein LppQ in Mycoplasma mycoides subsp. mycoides SC.
• Morphological and immunocytochemical analysis of Escherichia coli-specific surface antigens in wildtype strains and in recombinant Vibrio cholerae.
• Oligodendrocytes expressing exclusively the DM20 isoform of the proteolipid protein gene: myelination and development.
• Pancreatic islet expression studies and polymorphic DNA markers in the genes encoding hepatocyte nuclear factor-3alpha, -3beta, -3gamma, -4gamma, and -6.
• Regulation of apolipoprotein M gene expression by MODY3 gene hepatocyte nuclear factor-1alpha: haploinsufficiency is associated with reduced serum apolipoprotein M levels.
• Rumpshaker-like proteolipid protein (PLP) ratio in a mouse model with unperturbed structural and functional integrity of the myelin sheath and axons in the central nervous system.
• Specificity, duplex degradation and subcellular localization of antagomirs.
• Standing in the gap.
• [Dimensional stability of model materials for fixed partial dentures]
• [Good bye to Michael]
• [In Process Citation]
• [Synthesis of unsubstituted 3,5-dioxo-1,2,4-oxadiazolidines. 34. Hydroxylamine-derivatives]
• microRNAs and the regulation of glucose and lipid metabolism.