Pancreatic acinar-to-beta cell transdifferentiation in vitro.

Pancreatic acinar-to-beta cell transdifferentiation in vitro. Research Abstract Details 

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Pancreatic acinar-to-beta cell transdifferentiation in vitro. Abstract Text:

Although accumulating evidence indicates that proliferation of pre-existing beta-cells is the major mechanism of the maintenance of postnatal beta-cell mass, new beta-cells can be generated from non-beta-cells under certain conditions in vitro. We have recently shown directly by Cre/loxP-based cell lineage tracing that adult mouse pancreatic acinar cells can be transdifferentiated into insulin-secreting cells in vitro. These newly made cells secrete insulin in response to glucose and other secretagogues, but their secretory capacity is still low compared to that of native beta-cells. To improve the efficiency of generation of insulin-secreting cells from non-beta cells, it is critical to understand the molecular mechanism of such transdifferentiation. Since pancreatic acinar cells are the most abundant cell type in the pancreas, their utilization as a source of surrogate beta-cells is an intriguing approach to cell replacement therapy for type 1 diabetes. This review focuses on current knowledge of the regeneration of pancreatic beta-cells and transdifferentiation of pancreatic acinar-cells into insulin-secreting cells.

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Pancreatic acinar-to-beta cell transdifferentiation in vitro. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Frontiers in bioscience : a journal and virtual li

VOLUME: 13

Page Numbers: 5824-37

Journal Abbreviation: Front. Biosci.

ISSN: 1093-4715

DAY: 1

MONTH: 05

YEAR: 2008

Pancreatic acinar-to-beta cell transdifferentiation in vitro. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Pancreatic acinar-to-beta cell transdifferentiation in vitro.

AFFILIATION: Division of Cellular and Molecular Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.

Country: United States

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MEDLINETA: Front Biosci

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