Palmitate turnover and its response to glucose infusion in weight-losing cancer patients.

Palmitate turnover and its response to glucose infusion in weight-losing cancer patients. Research Abstract Details 

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Palmitate turnover and its response to glucose infusion in weight-losing cancer patients. Abstract Text:

O Selberg,D C McMillan,T Preston,H Carse,A Shenkin,H J Burns,

Palmitate turnover in weight-stable control subjects (n = 4) and weight-losing patients with progressive malignant disease (n = 4) has been determined. Measurements were made after an overnight fast and during glucose infusion (3.5 mg/kg/min). Turnover rates were calculated from plateau isotopic enrichment of palmitate in plasma during a continuous infusion of 1-13C palmitate. Palmitate turnover was higher in the cancer group before (180%) and during glucose loading (170%) compared with the control group. Palmitate turnover was reduced during glucose administration by approximately 34% in both groups. Plasma concentration of insulin was decreased and of cortisol was increased in the cancer group compared with the control group before and during glucose infusion. We conclude that cancer patients with weight loss have increased rates of fatty acid turnover indicative of enhanced mobilisation of body fat stores. Altered plasma concentrations of insulin and cortisol may mediate this effect. Nonetheless, even at more advanced stages of cachexia cancer patients have normal control mechanisms for inhibiting fatty acid turnover following administration of carbohydrate.

Palmitate turnover and its response to glucose infusion in weight-losing cancer patients. Publishing Authors By Initials

O Selberg,DC McMillan,T Preston,H Carse,A Shenkin,HJ Burns,

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Palmitate turnover and its response to glucose infusion in weight-losing cancer patients. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical nutrition (Edinburgh, Scotland)

VOLUME: 9

Page Numbers: 150-6

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ISSN: 0261-5614

DAY: 13

MONTH: Jun

YEAR: 1990

Palmitate turnover and its response to glucose infusion in weight-losing cancer patients. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Palmitate turnover and its response to glucose infusion in weight-losing cancer patients.

AFFILIATION: University Department of Surgery, Glasgow Royal Infirmary, Glasgow G4 0SF, UK.

Country: England

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MEDLINETA: Clin Nutr

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