Palliative gastrectomy and chemotherapy for stage IV gastric cancer.

Palliative gastrectomy and chemotherapy for stage IV gastric cancer. Research Abstract Details 

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Palliative gastrectomy and chemotherapy for stage IV gastric cancer. Abstract Text:

Sheng-Zhang Lin,Hong-Fei Tong,Tao You,Yao-Jun Yu,Wei-Jun Wu,Cong Chen,Wei Zhang,Bing Ye,Chun-Ming Li,Zhi-Qiang Zhen,Jia-Rong Xu,Jun-Liang Zhou,

PURPOSE: To investigate the value of palliative gastrectomy and chemotherapy in a large series of patients with stage IV gastric cancer. METHODS: A total of 389 patients were identified in survival analysis. Among which, 183 cases received palliative gastrectomy (PG) and 206 cases received unresectable operation, 184 cases received palliative chemotherapy (PC) and 205 cases did not receive chemotherapy. The survival advantages of patients, based on treatments modality, were also analyzed in patients with liver metastasis, peritoneal dissemination and lymph node metastasis. RESULTS: The 1-year, 3-year, 5-year survival rate of those patients who were treated with PG + PC were 85.7% (96/112), 32.1% (36/112), and 8.9% (10/112), which were far better than those who were not. For those patients with liver metastasis, peritoneal dissemination, and/or N3 lymph node metastasis, survival advantages were also present if treated with this multimodality approach. CONCLUSION: The survival time and palliative duration were significantly longer in patients after PG than after non-resection operations. Postoperative chemotherapy prolonged the survival time of patients after palliative surgery. PG combined with adjuvant chemotherapy may improve survival in patients with stage IV gastric cancer, even with liver metastasis, peritoneal dissemination, and lymph node metastasis.

Palliative gastrectomy and chemotherapy for stage IV gastric cancer. Publishing Authors By Initials

SZ Lin,HF Tong,T You,YJ Yu,WJ Wu,C Chen,W Zhang,B Ye,CM Li,ZQ Zhen,JR Xu,JL Zhou,

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Palliative gastrectomy and chemotherapy for stage IV gastric cancer. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of cancer research and clinical oncology

VOLUME: 134

Page Numbers: 187-92

Journal Abbreviation: J. Cancer Res. Clin. Oncol.

ISSN: 0171-5216

DAY: 5

MONTH: 07

YEAR: 2007

Palliative gastrectomy and chemotherapy for stage IV gastric cancer. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Palliative gastrectomy and chemotherapy for stage IV gastric cancer.

AFFILIATION: Department of General Surgery, Second Affiliated Hospital, Wenzhou Medical College, Wenzhou, 325027, China, wzf2lsz@163.com.

Country: Germany

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MEDLINETA: J Cancer Res Clin Oncol

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