Palladium(II) and Platinum(II) Organometallic Complexes with 4,7-dihydro-5-methyl-7-oxo[1,2,4]triazolo[1,5-a]pyrimidine. Antitumor Activity of the Platinum Compounds.

Palladium(II) and Platinum(II) Organometallic Complexes with 4,7-dihydro-5-methyl-7-oxo[1,2,4]triazolo[1,5-a]pyrimidine. Antitumor Activity of the Platinum Compounds. Research Abstract Details 

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Palladium(II) and Platinum(II) Organometallic Complexes with 4,7-dihydro-5-methyl-7-oxo[1,2,4]triazolo[1,5-a]pyrimidine. Antitumor Activity of the Platinum Compounds. Abstract Text:

Palladium and platinum complexes with HmtpO (where HmtpO = 4,7-dihydro-5-methyl-7-oxo[1,2,4]triazolo[1,5-a]pyrimidine, an analogue of the natural ocurring nucleobase hypoxanthine) of the types [M(dmba)(PPh 3)(HmtpO)]ClO 4 [dmba = N,C-chelating 2-(dimethylaminomethyl)phenyl; M = Pd or Pt], [Pd(N-N)(C 6F 5)(HmtpO)]ClO 4 [ N- N = 2,2'-bipyridine (bpy), 4,4'-dimethyl-2,2'-bipyridine (Me 2bpy), or N, N, N', N'-tetramethylethylenediamine (tmeda)] and cis-[M(C 6F 5) 2(HmtpO) 2] (M = Pd or Pt) (head-to-head atropisomer in the solid state) have been obtained. Pd(II) and Pt(II) complexes with the anion of HmtpO of the types [Pd(tmeda)(C 6F 5)(mtpO)], [Pd(dmba)(micro-mtpO)] 2, and [NBu 4] 2[M(C 6F 5) 2(micro-mtpO)] 2 (M = Pd or Pt) have been prepared starting from the corresponding hydroxometal complexes. Complexes containing simultaneously both the neutral HmtpO ligand and the anionic mtpO of the type [NBu 4][M(C 6F 5) 2(HmtpO)(mtpO)] (M = Pd or Pt) have been also obtained. In these mtpO-HmtpO metal complexes, for the first time, prototropic exchange is observed between the two heterocyclic ligands. The crystal structures of [Pd(dmba)(PPh 3)(HmtpO)] (+), cis-[Pt(C 6F 5) 2(HmtpO) 2].acetone, [Pd(C 6F 5)(tmeda)(mtpO)].2H 2O, [Pd(dmba)( micro-mtpO)] 2, [NBu 4] 2[Pd(C 6F 5) 2(micro-mtpO)] 2.CH 2Cl 2.toluene, [NBu 4] 2[Pt(C 6F 5) 2(micro-mtpO)] 2.0.5(toluene), and [NBu 4][Pt(C 6F 5) 2(mtpO)(HmtpO)] have been established by X-ray diffraction. Values of IC 50 were calculated for the new platinum complexes cis-[Pt(C 6F 5) 2(HmtpO) 2] and [Pt(dmba)(PPh 3)(HmtpO)]ClO 4 against a panel of human tumor cell lines representative of ovarian (A2780 and A2780 cisR), lung (NCI-H460), and breast cancers (T47D). At 48 h incubation time, both complexes were about 8-fold more active than cisplatin in T47D and show very low resistance factors against an A2780 cell line, which has acquired resistance to cisplatin. The DNA adduct formation of cis-[Pt(C 6F 5) 2(HmtpO) 2] and [Pt(dmba)(PPh 3)(HmtpO)]ClO 4 was followed by circular dichroism and electrophoretic mobility. Atomic force microscopy images of the modifications caused by these platinum complexes on plasmid DNA pB R322 were also obtained.

Palladium(II) and Platinum(II) Organometallic Complexes with 4,7-dihydro-5-methyl-7-oxo[1,2,4]triazolo[1,5-a]pyrimidine. Antitumor Activity of the Platinum Compounds. Publishing Authors By Initials

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Palladium(II) and Platinum(II) Organometallic Complexes with 4,7-dihydro-5-methyl-7-oxo[1,2,4]triazolo[1,5-a]pyrimidine. Antitumor Activity of the Platinum Compounds. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Inorganic chemistry

VOLUME: 47

Page Numbers: 4490-505

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ISSN: 0020-1669

DAY: 30

MONTH: 04

YEAR: 2008

Palladium(II) and Platinum(II) Organometallic Complexes with 4,7-dihydro-5-methyl-7-oxo[1,2,4]triazolo[1,5-a]pyrimidine. Antitumor Activity of the Platinum Compounds. Information

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LANGUAGE: eng

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Palladium(II) and Platinum(II) Organometallic Complexes with 4,7-dihydro-5-methyl-7-oxo[1,2,4]triazolo[1,5-a]pyrimidine. Antitumor Activity of the Platinum Compounds. Keywords Mesh Terms:

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Chemical & Substance for Abstract: Palladium(II) and Platinum(II) Organometallic Complexes with 4,7-dihydro-5-methyl-7-oxo[1,2,4]triazolo[1,5-a]pyrimidine. Antitumor Activity of the Platinum Compounds. Information

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AFFILIATION: Departamento de Química Inorgánica, Universidad de Murcia, E-30071- Murcia, Spain, jruiz@um.es.

Country: United States

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