PAK kinases are directly coupled to the PIX family of nucleotide exchange factors.

PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. Research Abstract Details 

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PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. Abstract Text:

E Manser,T H Loo,C G Koh,Z S Zhao,X Q Chen,L Tan,I Tan,T Leung,L Lim,

The PAK family of kinases are regulated through interaction with the small GTPases Cdc42 and Rac1, but little is known of the signaling components immediately upstream or downstream of these proteins. We have purified and cloned a new class of Rho-p21 guanine nucleotide exchange factor binding tightly through its N-terminal SH3 domain to a conserved proline-rich PAK sequence with a Kd of 24 nM. This PAK-interacting exchange factor (PIX), which is widely expressed and enriched in Cdc42- and Rac1-driven focal complexes, is required for PAK recruitment to these sites. PIX can induce membrane ruffling, with an associated activation of Rac1. Our results suggest a role for PIX in Cdc42-to-Rac1 signaling, involving the PIX/PAK complex.

PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. Publishing Authors By Initials

E Manser,TH Loo,CG Koh,ZS Zhao,XQ Chen,L Tan,I Tan,T Leung,L Lim,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure: molecular conformation: protein conformation: protein structure, tertiary: protein interaction domains and motifs: src homology domains research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure: molecular conformation: protein conformation: protein structure, tertiary: protein interaction domains and motifs: src homology domains research

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PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Molecular cell

VOLUME: 1

Page Numbers: 183-92

Journal Abbreviation: Mol. Cell

ISSN: 1097-2765

DAY: 19

MONTH: Jan

YEAR: 1998

PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9802571

PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. Keywords Mesh Terms:

KEYWORDS: src Homology Domains

MESH TERMS: genetics

Chemical & Substance for Abstract: PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. Information

Substance Name: rho GTP-Binding Proteins

Registry Number: EC 3.6.5.2

Grant and Affiliation Information for PAK kinases are directly coupled to the PIX family of nucleotide exchange factors.

AFFILIATION: Glaxo-IMCB Group, Institute of Molecular and Cell Biology, Singapore.

Country: UNITED STATES

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MEDLINETA: Mol Cell

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