Paclitaxel-octreotide conjugates inhibit growth of human non-small cell lung cancer cells in vitro.

Paclitaxel-octreotide conjugates inhibit growth of human non-small cell lung cancer cells in vitro. Research Abstract Details 

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Paclitaxel-octreotide conjugates inhibit growth of human non-small cell lung cancer cells in vitro. Abstract Text:

M L Sun,J M Wei,X W Wang,L Li,P Wang,M Li,C H Yi,M L Sun,J M Wei,X W Wang,L Li,P Wang,M Li,C H Yi,M L Sun,J M Wei,X W Wang,L Li,P Wang,M Li,C H Yi,

AIM: To evaluate the effects of paclitaxel-octreotide conjugates on the growth of cultured non-small cell lung cancer cells. METHODS: RT-PCR was performed to detect mRNA for the subtypes of the human somatostatin receptor (SSTR) using specific primers. MTT-based cytotoxicity assay was used to evaluate the cell viability after treatment with paclitaxel and the conjugates. Cell cycle perturbations were determined using a Fluorescence-Activated Cell Sorter. RESULTS: Non-small cell lung cancer A549 and Calu-6 cells expressed mRNA for SSTR2 and SSTR5. Paclitaxel and the conjugates effectively inhibited the growth of A549 and Calu-6 cells in a concentration- and time-dependent manner. In SSTR-negative fibroblasts, the conjugates were less cytotoxic than paclitaxel. The conjugates and paclitaxel could induce the increase of G(2)/M phase ratio in A549 cells. CONCLUSION: The paclitaxel-octreotide conjugates can be used as selective-targeted chemotherapeutic agents for treating non-small cell lung cancer.

Paclitaxel-octreotide conjugates inhibit growth of human non-small cell lung cancer cells in vitro. Publishing Authors By Initials

ML Sun,JM Wei,XW Wang,L Li,P Wang,M Li,CH Yi,ML Sun,JM Wei,XW Wang,L Li,P Wang,M Li,CH Yi,ML Sun,JM Wei,XW Wang,L Li,P Wang,M Li,CH Yi,

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Paclitaxel-octreotide conjugates inhibit growth of human non-small cell lung cancer cells in vitro. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Experimental oncology

VOLUME: 29

Page Numbers: 186-91

Journal Abbreviation: Exp. Oncol.

ISSN: 1812-9269

DAY: 16

MONTH: Sep

YEAR: 2007

Paclitaxel-octreotide conjugates inhibit growth of human non-small cell lung cancer cells in vitro. Information

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LANGUAGE: eng

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AFFILIATION: Department of Oncology, Qilu Hospital, Shandong University, Jinan, 250012, China. wangxw12@yahoo.com.

Country: Ukraine

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MEDLINETA: Exp Oncol

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