p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors.

p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors. Research Abstract Details 

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p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors. Abstract Text:

Senta Georgia,Rosemary Soliz,Min Li,Pumin Zhang,Anil Bhushan,

In developing organs, the regulation of cell proliferation and cell cycle exit is coordinated. How this coordination is achieved, however, is not clear. We show that the cyclin kinase inhibitor p57 regulates cell cycle exit of progenitors during the early stages of pancreas formation. In the absence of p57, the number of cycling progenitors increases, although expansion of progenitor population is prevented by apoptosis. We report that p57 is a direct target of transcriptional repression by Notch effector, Hes1. Inactivation of Hes1 results in the upregulation of p57 expression in progenitors, leading to cell cycle arrest, precocious differentiation and depletion of the progenitor pool. We present evidence that in p57/Hes1 double null embryos, the absence of apoptosis results in the expansion of the progenitor population. We propose that Hes1 and p57 not only coordinate cell cycle exit and self-renewal of pancreatic progenitors during an early stage in organogenesis to regulate the number of pancreatic progenitors, but could also constitute a surveillance system to eliminate cells with aberrant cell cycle characteristics.

p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors. Publishing Authors By Initials

S Georgia,R Soliz,M Li,P Zhang,A Bhushan,

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p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Developmental biology

VOLUME: 298

Page Numbers: 22-31

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ISSN: 0012-1606

DAY: 2

MONTH: 06

YEAR: 2006

p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors. Information

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LANGUAGE: eng

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Grant and Affiliation Information for p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors.

AFFILIATION: Larry Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

Country: United States

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MEDLINETA: Dev Biol

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