p53, cellular proliferation, and apoptosis-related factors in thymic neuroendocrine tumors.

p53, cellular proliferation, and apoptosis-related factors in thymic neuroendocrine tumors. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

p53, cellular proliferation, and apoptosis-related factors in thymic neuroendocrine tumors. Abstract Text:

Anthony A Gal,Mary N Sheppard,John D L Nolen,Cynthia Cohen,

Thymic neuroendocrine tumors are biologically aggressive neoplasms with extensive local invasion and high mortality. Although various markers of cellular proliferation and apoptosis have correlated with degrees of tumor differentiation in pulmonary neuroendocrine neoplasms, they have not been systematically studied in thymic neuroendocrine tumors. We immunostained 21 cases of thymic neuroendocrine tumors for p53, MIB-1, and the apoptosis-related markers Bcl-2, Bcl-x, and Bax. By histological classification the cases were low-grade (nine cases), intermediate-grade (eight cases), and high-grade (four cases) thymic neuroendocrine tumors. p53 was expressed in five cases: 1/9 low grade, 3/8 intermediate grade, and 2/4 high grade. The mean cellular proliferation (MIB-1) was 7.1% (range 2-12%) in low-grade thymic neuroendocrine tumors, 6.1% (range 2-15%) in intermediate-grade thymic neuroendocrine tumors, and 34.2% (range 2-80%) in high-grade thymic neuroendocrine tumors. Bcl-2 was expressed in 16 cases: 7/9 low grade, 5/8 intermediate grade, and 4/4 high grade. Bcl-x was expressed in 16 cases: 7/9 low grade, 6/8 intermediate grade, and 3/4 high grade. Bax was expressed in 13 cases: 5/9 low grade, 4/8 intermediate grade, and 4/4 high grade. The presence of mutant p53 in the tumor was associated with a statistically significant decreased mean survival (P<0.05). In contrast, either by positive or negative staining or by the score technique (staining intensity x percentage of cells staining), the presence of Bcl-x was associated with an increased mean survival (P<0.05). Finally, a Bcl-x : Bax ratio >/=1 was also associated with an increased mean survival, as compared to a Bcl-x : Bax ratio >/=1 (P<0.05). Our study shows that p53 expression and certain apoptosis markers correlate with survival. The expression of these markers may account for differences in biological behavior.Modern Pathology (2004) 17, 33-39, advance online publication, 19 November 2003; doi:10.1038/modpathol.3800009

p53, cellular proliferation, and apoptosis-related factors in thymic neuroendocrine tumors. Publishing Authors By Initials

AA Gal,MN Sheppard,JD Nolen,C Cohen,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

p53, cellular proliferation, and apoptosis-related factors in thymic neuroendocrine tumors. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Modern pathology : an official journal of the Unit

VOLUME: 17

Page Numbers: 33-9

Journal Abbreviation: Mod. Pathol.

ISSN: 0893-3952

DAY: 31

MONTH: Jan

YEAR: 2004

p53, cellular proliferation, and apoptosis-related factors in thymic neuroendocrine tumors. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8806605

p53, cellular proliferation, and apoptosis-related factors in thymic neuroendocrine tumors. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: p53, cellular proliferation, and apoptosis-related factors in thymic neuroendocrine tumors. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for p53, cellular proliferation, and apoptosis-related factors in thymic neuroendocrine tumors.

AFFILIATION: 1Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Mod Pathol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

p53, cellular proliferation, and apoptosis-related factors in thymic neuroendocrine tumors Related Publications

• A polymorphism in New Zealand inbred mouse strains that inactivates phosphatidylcholine transfer protein.
• A standards-based approach for facilitating discovery of learning objects at the point of care.
• Atrial natriuretic peptide administered just prior to reperfusion limits infarction in rabbit hearts.
• Biomarkers in the diagnosis of Alzheimer's disease: are we ready?
• Cognitive predictors of functional decline in vascular dementia.
• Crohn's disease arthritis treated with infliximab: an open trial in four patients.
• Cryosurgery of the prostate: techniques and indications.
• Determination of ethylenediaminetetra-acetic acid in aqueous rinses of detergent-washed rubber stoppers of pharmaceutical vials using solid-phase extraction and capillary gas chromatography.
• Electrical activation of the human vestibulo-sympathetic reflex.
• Functional magnetic resonance imaging and magnetoencephalography differences associated with APOEepsilon4 in young healthy adults.
• Homozygous disruption of Pctp modulates atherosclerosis in apolipoprotein E-deficient mice.
• Identification and characterization of a human monoclonal antagonistic antibody AL-57 that preferentially binds the high-affinity form of lymphocyte function-associated antigen-1.
• Identification of a GABAA receptor anesthetic binding site at subunit interfaces by photolabeling with an etomidate analog.
• Impulsivity and the reinforcing value of cigarette smoking.
• Management of refractory ulcerative colitis.
• Mental health services for victims of disasters.
• Mental health services in primary care in 'developing' countries.
• Optimism, distress, health-related quality of life, and change in cancer antigen 125 among patients with ovarian cancer undergoing chemotherapy.
• Phosphorylation by DNA-dependent protein kinase is critical for apoptosis induction by insulin-like growth factor binding protein-3.
• Primary prevention in high-risk dyslipidemic patients without an established cardiovascular disease: Undertreatment and rationale for lipid-lowering therapy.
• Social role and birth cohort influences on gender-linked personality traits in women: a 20-year longitudinal analysis.
• TSA-induced cell death in prostate cancer cell lines is caspase-2 dependent and involves the PIDDosome.
• The cost-effectiveness of treating male trichomoniasis to avert HIV transmission in men seeking sexually transmitted disease care in Malawi.
• The physics of optimal decision making: a formal analysis of models of performance in two-alternative forced-choice tasks.
• The proximal convoluted tubule is a target for the uroguanylin-regulated natriuretic response.
• Treatment strategies for medulloblastoma and primitive neuroectodermal tumors.
• Writing about the benefits of an interpersonal transgression facilitates forgiveness.
• [Spatial orientation of the vestibulo-ocular reflex]
• [The effects of neuroleptics and social research in psychopharmacology.]
• p53, cellular proliferation, and apoptosis-related factors in thymic neuroendocrine tumors.