p51A (TAp63gamma), a p53 homolog, accumulates in response to DNA damage for cell regulation.

p51A (TAp63gamma), a p53 homolog, accumulates in response to DNA damage for cell regulation. Research Abstract Details 

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p51A (TAp63gamma), a p53 homolog, accumulates in response to DNA damage for cell regulation. Abstract Text:

p51A, or TAp63gamma, a translation product of gene p51, or p63, was identified as a homolog of p53 in its primary structure and transactivating function. p53 plays a decision-making role in inducing either cell cycle arrest or apoptosis in response to DNA damage, and thereby preserves genome integrity of living cells. To compare the biological activities between p51A and p53, cell lines with low-level, constitutive expression of each protein were obtained by cDNA transfection of mouse erythroleukemic cells. Production of p51A with an apparent molecular mass of 57-kilodalton (kD) accompanied induction of p21waf1 and appearance of hemoglobin-producing cells. After DNA-damaging treatment either with ultraviolet light (UV) irradiation or with actinomycin D, the p51A protein accumulated in time courses corresponding to those of wild-type p53, and caused an increase in the hemoglobin-positive cell count. In contrast, p53-accumulated cells underwent apoptosis without exhibiting the feature of erythroid differentiation. The mode of p21waf1 and Bax-alpha upregulations varied between p51A- and p53-expressing cells and between the types of DNA damage. These results suggest the possibility that p51A induces differentiation under genotoxic circumstances. There may be cellular factors that control p51A protein stability and transactivating ability.

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p51A (TAp63gamma), a p53 homolog, accumulates in response to DNA damage for cell regulation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Oncogene

VOLUME: 19

Page Numbers: 3126-30

Journal Abbreviation: Oncogene

ISSN: 0950-9232

DAY: 22

MONTH: Jun

YEAR: 2000

p51A (TAp63gamma), a p53 homolog, accumulates in response to DNA damage for cell regulation. Information

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LANGUAGE: eng

NlmUniqueID: 8711562

p51A (TAp63gamma), a p53 homolog, accumulates in response to DNA damage for cell regulation. Keywords Mesh Terms:

KEYWORDS: bcl-2-Associated X Protein

MESH TERMS: metabolism

Chemical & Substance for Abstract: p51A (TAp63gamma), a p53 homolog, accumulates in response to DNA damage for cell regulation. Information

Substance Name: Dactinomycin

Registry Number: 50-76-0

Grant and Affiliation Information for p51A (TAp63gamma), a p53 homolog, accumulates in response to DNA damage for cell regulation.

AFFILIATION: Department of Retroviral Regulation, Medical Research Division, Tokyo Medical and Dental University, Tokyo 113-8519, Japan.

Country: ENGLAND

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MEDLINETA: Oncogene

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