p40phox as an alternative organizer to p47phox in Nox2 activation: a new mechanism involving an interaction with p22phox.

p40phox as an alternative organizer to p47phox in Nox2 activation: a new mechanism involving an interaction with p22phox. Research Abstract Details 

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p40phox as an alternative organizer to p47phox in Nox2 activation: a new mechanism involving an interaction with p22phox. Abstract Text:

Minoru Tamura,Iichiro Shiozaki,Shohei Ono,Kei Miyano,Sachio Kunihiro,Takayuki Sasaki,Minoru Tamura,Iichiro Shiozaki,Shohei Ono,Kei Miyano,Sachio Kunihiro,Takayuki Sasaki,

p40(phox) activated phagocyte NADPH oxidase without p47(phox) in a cell-free system consisting of p67(phox), Rac and cytochrome b(558) relipidated with phosphatidylinositol 3-phosphate. The activation reached to 70% of that by p47(phox). Addition of p47(phox) slightly increased the activation, but not additively. p40(phox) improved the efficiency of p67(phox) in the activation. The C-terminus-truncated p67(phox), p40(phox)(D289A), p40(phox)(R58A), or p40(phox)(W207R) showed an impaired activation. A peptide corresponding to the p22(phox) Pro-rich region suppressed the activation, and far-western blotting revealed its interaction with p40(phox) SH3 domain. Thus, p40(phox) can substitute for p47(phox) in the activation, interacting with p22(phox) and p67(phox) through their specific regions.

p40phox as an alternative organizer to p47phox in Nox2 activation: a new mechanism involving an interaction with p22phox. Publishing Authors By Initials

M Tamura,I Shiozaki,S Ono,K Miyano,S Kunihiro,T Sasaki,M Tamura,I Shiozaki,S Ono,K Miyano,S Kunihiro,T Sasaki,

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p40phox as an alternative organizer to p47phox in Nox2 activation: a new mechanism involving an interaction with p22phox. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: FEBS letters

VOLUME: 581

Page Numbers: 4533-8

Journal Abbreviation: FEBS Lett.

ISSN: 0014-5793

DAY: 27

MONTH: 08

YEAR: 2007

p40phox as an alternative organizer to p47phox in Nox2 activation: a new mechanism involving an interaction with p22phox. Information

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LANGUAGE: eng

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AFFILIATION: Department of Applied Chemistry, Graduate School of Science and Engineering, Ehime University, Matsuyama, Ehime 790-8577, Japan. tamura@eng.ehime-u.ac.jp

Country: Netherlands

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MEDLINETA: FEBS Lett

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