P2X(7) receptors: properties and relevance to CNS function.

P2X(7) receptors: properties and relevance to CNS function. Research Abstract Details 

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P2X(7) receptors: properties and relevance to CNS function. Abstract Text:

Shumin Duan,Joseph T Neary,

Among seven members of P2X ionotropic receptors activated by extracellular ATP, the P2X(7) subtype is unique in that it can function as a cation channel, a nonselective pore, or even a signaling complex coupled with multiple downstream components. Several roles of P2X(7) receptors have been described in CNS cells in the past decade, including release of cytokines and transmitters, modulation of presynaptic transmitter release, and activation of multiple signaling pathways. The finding that P2X(7) pores may directly mediate efflux of cytosolic glutamate, GABA, and ATP in glial cells is particularly interesting, as it provides a novel mechanism of glial transmitter release that may play important roles not only in physiological intercellular communication but also in pathological neural injury.

P2X(7) receptors: properties and relevance to CNS function. Publishing Authors By Initials

S Duan,JT Neary,

For similar synaptic transmission research abstracts see: synaptic transmission research

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P2X(7) receptors: properties and relevance to CNS function. Journal Published:

PUBLICATION TYPE: Review

Journal: Glia

VOLUME: 54

Page Numbers: 738-46

Journal Abbreviation: Glia

ISSN: 0894-1491

DAY: 15

MONTH: Nov

YEAR: 2006

P2X(7) receptors: properties and relevance to CNS function. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8806785

P2X(7) receptors: properties and relevance to CNS function. Keywords Mesh Terms:

KEYWORDS: Synaptic Transmission

MESH TERMS: physiology

Chemical & Substance for Abstract: P2X(7) receptors: properties and relevance to CNS function. Information

Substance Name: Adenosine Triphosphate

Registry Number: 56-65-5

Grant and Affiliation Information for P2X(7) receptors: properties and relevance to CNS function.

AFFILIATION: Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China. shumin@ion.ac.cn

Country: United States

AGENCY: United States NINDS

GRANT: NS46651

ACRONYM: NS

MEDLINETA: Glia

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