p16INK4a Gene Promoter Hypermethylation in Mucosa as a Prognostic Factor for Patients with Colorectal Cancer.

p16INK4a Gene Promoter Hypermethylation in Mucosa as a Prognostic Factor for Patients with Colorectal Cancer. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

p16INK4a Gene Promoter Hypermethylation in Mucosa as a Prognostic Factor for Patients with Colorectal Cancer. Abstract Text:

Low gene expression of folylpolyglutamate synthase (FPGS) in colorectal mucosa correlates with low folate levels and poor survival of colorectal cancer (CRC) patients. Because gene-specific hypermethylation is affected by the folate level, the hypermethylation status in mucosa may also be linked to clinical outcome of CRC patients. The tumor suppressor gene p16INK4a (p16) regulates the cell cycle and angiogenic switch. In human neoplastic tissues, the main mechanism of p16 inactivation is promoter methylation. The aim of the study was to determine whether hypermethylation of the p16 promoter could be detected in mucosa of CRC patients (n = 181) and to analyze if hypermethylation was related to survival. The relation between p16 hypermethylation and expression of FPGS and two other folate-associated genes, reduced folate carrier 1 (RFC-1), and thymidylate synthase (TS), was analyzed (n = 63). The results showed that p16 was hypermethylated in 65 (36%) of the mucosa samples and that hypermethylation was age-related (P = 0.029). After adjustment for known risk factors, Cox regression analysis showed that Dukes' A-C patients with p16 hypermethylation in mucosa had an increased risk of cancer-related death (hazard ratio = 2.9, P = 0.007) and shorter disease-free survival (hazard ratio = 2.5, P = 0.015) compared with patients with no p16 hypermethylation. RFC-1 and FPGS gene expression levels were significantly correlated in patients lacking p16 hypermethylation in mucosa (P = 0.0003), but not at all correlated in patients having hypermethylation in mucosa (P = 1.0). In conclusion, p16 hypermethylation in mucosa of CRC patients was identified as an independent prognostic parameter for cancer-specific survival as well as an independent predictor of DFS. The results suggest that there might be a connection between folate-associated gene expression and p16 methylation status.

p16INK4a Gene Promoter Hypermethylation in Mucosa as a Prognostic Factor for Patients with Colorectal Cancer. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE: 2008 Jul-Aug

p16INK4a Gene Promoter Hypermethylation in Mucosa as a Prognostic Factor for Patients with Colorectal Cancer. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Molecular medicine (Cambridge, Mass.)

VOLUME: 14

Page Numbers: 412-21

Journal Abbreviation: Mol. Med.

ISSN: 1076-1551

DAY: 16

MONTH: 07

YEAR: 2008

p16INK4a Gene Promoter Hypermethylation in Mucosa as a Prognostic Factor for Patients with Colorectal Cancer. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9501023

p16INK4a Gene Promoter Hypermethylation in Mucosa as a Prognostic Factor for Patients with Colorectal Cancer. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: p16INK4a Gene Promoter Hypermethylation in Mucosa as a Prognostic Factor for Patients with Colorectal Cancer. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for p16INK4a Gene Promoter Hypermethylation in Mucosa as a Prognostic Factor for Patients with Colorectal Cancer.

AFFILIATION: Department of General Surgery, Göteborg University, Sahlgrenska University Hospital/Ostra, Göteborg, Sweden.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Mol Med

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

p16INK4a Gene Promoter Hypermethylation in Mucosa as a Prognostic Factor for Patients with Colorectal Cancer Related Publications

• A study of lymph node ratio as a prognostic marker in colon cancer.
• An Internet-based videoconferencing system for supporting frail elderly people and their carers.
• An ultrastructural study of the cuticle in the marine annelid Heterodrilus (Tubificidae, Clitellata).
• Assessing informal caregivers' experiences: a qualitative and psychometric evaluation of the Caregiver Reaction Assessment Scale.
• Biosensor analysis of beta-lactams in milk using the carboxypeptidase activity of a bacterial penicillin binding protein.
• Central nervous system tumours of childhood, clinics in developmental medicine number 166.
• Colorectal carcinomas with microsatellite instability display increased thymidylate synthase gene expression levels.
• Compensation method for attenuated planar laser images of optically dense sprays.
• Determination of fumonisins B1 and B2 in various maize products by a combined SAX + C18 column and immunoaffinity column.
• Different response alternatives in the assessment of job demands.
• Embryo quality and andrological study of two subfertile bulls versus five control bulls with normal fertility.
• Exposure to particles and nitrogen dioxide among taxi, bus and lorry drivers.
• Generic and professional outcomes of a general nursing education program - a national study of higher education.
• Hand-assisted laparoscopic Roux-en-y gastric bypass: aspects of surgical technique and early results.
• Health-related quality of life in significant others of patients dying from lung cancer.
• Investigation of the excluded stomach after Roux-en-Y gastric bypass.
• Laparoscopic vs open Roux-en-Y gastric bypass: a prospective, randomized trial.
• Method for damping vibrations and a method for mounting the device.
• Monoclonal antibodies for detection of Campylobacter pylori in biopsy smears and frozen sections.
• Myocardial infarction in Swedish subway drivers.
• Peptic ulcer disease--trends in surgical management in Sweden.
• Recent studies on transmissible agent in Crohn's disease.
• Role of gastric acid in stomal ulcer after gastric bypass.
• Silicone-adjustable gastric banding: disappointing results.
• Temperature and vibration thresholds in vibration syndrome.
• The echogenecity of the intima-media complex in the common carotid artery is closely related to the echogenecity in plaques.
• Ultrastructural investigation of coelomocytes in representatives of Naidinae and Rhyacodrilinae (Annelida, Clitellata, Tubificidae).
• [In Process Citation]
• [Spinal anaesthesia in gynaecology and obstetrics.]
• p16INK4a Gene Promoter Hypermethylation in Mucosa as a Prognostic Factor for Patients with Colorectal Cancer.