p16(CDKN2) gene polymorphism: association with histologic subtypes of epithelial ovarian cancer in China.

p16(CDKN2) gene polymorphism: association with histologic subtypes of epithelial ovarian cancer in China. Research Abstract Details 

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p16(CDKN2) gene polymorphism: association with histologic subtypes of epithelial ovarian cancer in China. Abstract Text:

L Yan,W Na,K Shan,M Xiao-Wei,G Wei,C Shu-Cheng,L Yan,W Na,K Shan,M Xiao-Wei,G Wei,C Shu-Cheng,L Yan,W Na,K Shan,M Xiao-Wei,G Wei,C Shu-Cheng,

p16 is an important tumor suppressor gene, which is inactivated in many kinds of tumors. The common variants of p16 may be associated with the risk of certain tumors development. We analyzed the frequency of two adjacent polymorphisms in p16 exon 3 (540C-->G and 580C-->T) and their haplotype in blood samples from epithelial ovarian cancer (EOC) patients and healthy controls using polymerase chain reaction-restriction fragment length polymorphism. The results showed that the genotype frequency of p16 580C-->T polymorphism was significantly different among histologic subtypes of EOC (P= 0.02). T allele carriers significantly reduced the risk of serous EOC; the adjusted odds ratio was 0.40 (95% CI = 0.19-0.84). There are neither association between p16 540C-->G polymorphism and EOC development, progression, nor association between the haplotypes of two single nucleotide polymorphisms and the tumor development. Our results suggested that the p16 580C-->T polymorphism might affect the individual susceptibility to specific subtypes of EOC. Different types of ovarian cancer might adopt distinct carcinogenetic pathways. However, this result may be further validated in a larger sample of patients.

p16(CDKN2) gene polymorphism: association with histologic subtypes of epithelial ovarian cancer in China. Publishing Authors By Initials

L Yan,W Na,K Shan,M Xiao-Wei,G Wei,C Shu-Cheng,L Yan,W Na,K Shan,M Xiao-Wei,G Wei,C Shu-Cheng,L Yan,W Na,K Shan,M Xiao-Wei,G Wei,C Shu-Cheng,

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PUBMED ID PMID:

MEDLINE DATE: 2008 Jan-Feb

p16(CDKN2) gene polymorphism: association with histologic subtypes of epithelial ovarian cancer in China. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of gynecological cancer : of

VOLUME: 18

Page Numbers: 30-5

Journal Abbreviation: Int. J. Gynecol. Cancer

ISSN: 1048-891X

DAY: 26

MONTH: 04

YEAR: 2007

p16(CDKN2) gene polymorphism: association with histologic subtypes of epithelial ovarian cancer in China. Information

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LANGUAGE: eng

NlmUniqueID: 9111626

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Grant and Affiliation Information for p16(CDKN2) gene polymorphism: association with histologic subtypes of epithelial ovarian cancer in China.

AFFILIATION: Department of Molecular Biology, Hebei Medical University, Fourth Hospital, Shijiazhuang, China.

Country: United States

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MEDLINETA: Int J Gynecol Cancer

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