P0 protein is required for and can induce formation of schmidt-lantermann incisures in myelin internodes.

P0 protein is required for and can induce formation of schmidt-lantermann incisures in myelin internodes. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

P0 protein is required for and can induce formation of schmidt-lantermann incisures in myelin internodes. Abstract Text:

Axons in the PNS and CNS are ensheathed by multiple layers of tightly compacted myelin membranes. A series of cytoplasmic channels connect outer and inner margins of PNS, but not CNS, myelin internodes. Membranes of these Schmidt-Lantermann (S-L) incisures contain the myelin-associated glycoprotein (MAG) but not P(0) or proteolipid protein (PLP), the structural proteins of compact PNS (P(0)) and CNS (PLP) myelin. We show here that incisures are present in MAG-null and absent from P(0)-null PNS internodes. To test the possibility that P(0) regulates incisure formation, we replaced PLP with P(0) in CNS myelin. S-L incisures formed in P(0)-CNS myelin internodes. Furthermore, axoplasm ensheathed by 65% of the CNS incisures examined by electron microscopy had focal accumulations of organelles, indicating that these CNS incisures disrupt axonal transport. These data support the hypotheses that P(0) protein is required for and can induce S-L incisures and that P(0)-induced CNS incisures can be detrimental to axonal function.

P0 protein is required for and can induce formation of schmidt-lantermann incisures in myelin internodes. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

P0 protein is required for and can induce formation of schmidt-lantermann incisures in myelin internodes. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of neuroscience : the official journal

VOLUME: 28

Page Numbers: 7068-73

Journal Abbreviation: J. Neurosci.

ISSN: 1529-2401

DAY: 9

MONTH: Jul

YEAR: 2008

P0 protein is required for and can induce formation of schmidt-lantermann incisures in myelin internodes. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8102140

P0 protein is required for and can induce formation of schmidt-lantermann incisures in myelin internodes. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: P0 protein is required for and can induce formation of schmidt-lantermann incisures in myelin internodes. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for P0 protein is required for and can induce formation of schmidt-lantermann incisures in myelin internodes.

AFFILIATION: Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS 38186

ACRONYM: NS

MEDLINETA: J Neurosci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

P0 protein is required for and can induce formation of schmidt-lantermann incisures in myelin internodes Related Publications

• Activation of the ciliary neurotrophic factor (CNTF) signalling pathway in cortical neurons of multiple sclerosis patients.
• Axon-glial signaling and the glial support of axon function.
• Cyclosporin A: correlation between HPLC and RIA serum levels.
• Distribution of immunoglobulin superfamily members ICAM-1, -2, -3, and the beta 2 integrin LFA-1 in multiple sclerosis lesions.
• Enhanced diffusion of polycyclic aromatic hydrocarbons in artificial and natural aqueous solutions.
• First-episode schizophrenics show normal duration and topography of quasistationary EEG segments as compared to controls, during rest as well as during active tasks.
• Gas chromatographic high-throughput screening techniques in catalysis.
• Imaging correlates of axonal swelling in chronic multiple sclerosis brains.
• Imaging correlates of decreased axonal Na+/K+ ATPase in chronic multiple sclerosis lesions.
• Is there room for improvement in the emollients for adjuvant therapy?
• Meteorological influence on the occurrence of gastric dilatation-volvulus in military working dogs in Texas.
• Microevolutionary patterns and processes of the Native Hawaiian colonizing fern Odontosoria chinensis (Lindsaeaceae).
• NG2-positive cells generate A2B5-positive oligodendrocyte precursor cells.
• Neurogenesis in the chronic lesions of multiple sclerosis.
• P0 protein is required for and can induce formation of schmidt-lantermann incisures in myelin internodes.
• Pathogenesis of axonal and neuronal damage in multiple sclerosis.
• Rescue of congenital hypomyelination by progenitor cell transplantation.
• Sensing on a molecular level--chemistry at the interface of information technology.
• The clinical application of PET/CT: a contemporary review.
• The quantitative evaluation of bone density.
• True believer.
• Uptake, removal, accumulation, and phytotoxicity of 4-chlorophenol in willow trees.