Ozone, oxidant defense genes, and risk of asthma during adolescence.

Ozone, oxidant defense genes, and risk of asthma during adolescence. Research Abstract Details 

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Ozone, oxidant defense genes, and risk of asthma during adolescence. Abstract Text:

Talat Islam,Rob McConnell,W James Gauderman,Ed Avol,John M Peters,Frank D Gilliland,

RATIONALE: Although oxidative stress is a cardinal feature of asthma, the roles of oxidant air pollutants and antioxidant genes heme oxygenase 1 (HMOX-1), catalase (CAT), and manganese superoxide dismutase (MNSOD) in asthma pathogenesis have yet to be determined. OBJECTIVES: We hypothesized that the functional polymorphisms of HMOX-1 ([GT](n) repeat), CAT (-262C>T -844C>T), and MNSOD (Ala-9Val) are associated with new-onset asthma, and the effects of these variants vary by exposure to ozone, a potent oxidant air pollutant. Methods: We assessed this hypothesis in a population-based cohort of non-Hispanic (n = 1,125) and Hispanic white (n = 586) children who resided in 12 California communities and who were followed annually for 8 years to ascertain new-onset asthma. MEASUREMENTS AND MAIN RESULTS: Air pollutants were continuously measured in each of the study communities during the 8 years of study follow-up. HMOX-1 "short" alleles (<23 repeats) were associated with a reduced risk for new-onset asthma among non-Hispanic whites (hazard ratio [HR], 0.64; 95% confidence interval [CI], 0.41-0.99). This protective effect was largest in children residing in low-ozone communities (HR, 0.48; 95% CI, 0.25-0.91) (interaction P value = 0.003). Little evidence for an association with HMOX-1 was observed among Hispanic children. In contrast, Hispanic children with a variant of the CAT-262 "T" allele (CT or TT) had an increased risk for asthma (HR, 1.78; P value = 0.01). The effects of these polymorphisms were not modified by personal smoking or secondhand-smoke exposure. CONCLUSIONS: Functional promoter variants in CAT and HMOX-1 showed ethnicity-specific associations with new-onset asthma. Oxidant gene protection was restricted to children living in low-ozone communities.

Ozone, oxidant defense genes, and risk of asthma during adolescence. Publishing Authors By Initials

T Islam,R McConnell,WJ Gauderman,E Avol,JM Peters,FD Gilliland,

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Ozone, oxidant defense genes, and risk of asthma during adolescence. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: American journal of respiratory and critical care

VOLUME: 177

Page Numbers: 388-95

Journal Abbreviation: Am. J. Respir. Crit. Care Med.

ISSN: 1535-4970

DAY: 29

MONTH: 11

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 9421642

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Grant and Affiliation Information for Ozone, oxidant defense genes, and risk of asthma during adolescence.

AFFILIATION: M.D. Department of Preventive Medicine, USC Keck School of Medicine, 1540 Alcazar Street, CHP 236, Los Angeles, CA 90033, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: 5R01HL076647

ACRONYM: HL

MEDLINETA: Am J Respir Crit Care Med

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