Oxytocin increases retention of social cognition in autism.

Oxytocin increases retention of social cognition in autism. Research Abstract Details 

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Oxytocin increases retention of social cognition in autism. Abstract Text:

Eric Hollander,Jennifer Bartz,William Chaplin,Ann Phillips,Jennifer Sumner,Latha Soorya,Evdokia Anagnostou,Stacey Wasserman,

BACKGROUND: Oxytocin dysfunction might contribute to the development of social deficits in autism, a core symptom domain and potential target for intervention. This study explored the effect of intravenous oxytocin administration on the retention of social information in autism. METHODS: Oxytocin and placebo challenges were administered to 15 adult subjects diagnosed with autism or Asperger's disorder, and comprehension of affective speech (happy, indifferent, angry, and sad) in neutral content sentences was tested. RESULTS: All subjects showed improvements in affective speech comprehension from pre- to post-infusion; however, whereas those who received placebo first tended to revert to baseline after a delay, those who received oxytocin first retained the ability to accurately assign emotional significance to speech intonation on the speech comprehension task. CONCLUSIONS: These results are consistent with studies linking oxytocin to social recognition in rodents as well as studies linking oxytocin to prosocial behavior in humans and suggest that oxytocin might facilitate social information processing in those with autism. These findings also provide preliminary support for the use of oxytocin in the treatment of autism.

Oxytocin increases retention of social cognition in autism. Publishing Authors By Initials

E Hollander,J Bartz,W Chaplin,A Phillips,J Sumner,L Soorya,E Anagnostou,S Wasserman,

For similar behavior and behavior mechanisms: behavior: communication: verbal behavior: speech research abstracts see: behavior and behavior mechanisms: behavior: communication: verbal behavior: speech research

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Oxytocin increases retention of social cognition in autism. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biological psychiatry

VOLUME: 61

Page Numbers: 498-503

Journal Abbreviation: Biol. Psychiatry

ISSN: 0006-3223

DAY: 14

MONTH: 08

YEAR: 2006

Oxytocin increases retention of social cognition in autism. Information

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LANGUAGE: eng

NlmUniqueID: 213264

Oxytocin increases retention of social cognition in autism. Keywords Mesh Terms:

KEYWORDS: Speech

MESH TERMS: drug effects

Chemical & Substance for Abstract: Oxytocin increases retention of social cognition in autism. Information

Substance Name: Oxytocin

Registry Number: 50-56-6

Grant and Affiliation Information for Oxytocin increases retention of social cognition in autism.

AFFILIATION: Mount Sinai School of Medicine, New York, New York, USA. eric.hollander@mssm.edu

Country: United States

AGENCY: United States NIMH

GRANT: 5 U54 MH066673-03

ACRONYM: MH

MEDLINETA: Biol Psychiatry

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