Oxygen pressures in the interstitial space of skeletal muscle and tumors in vivo.

Oxygen pressures in the interstitial space of skeletal muscle and tumors in vivo. Research Abstract Details 

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Oxygen pressures in the interstitial space of skeletal muscle and tumors in vivo. Abstract Text:

David F Wilson,William M F Lee,Sosina Makonnen,Sophia Apreleva,Sergei A Vinogradov,David F Wilson,William M F Lee,Sosina Makonnen,Sophia Apreleva,Sergei A Vinogradov,

A new Oxyphor (Oxyphor G3) has been used to selectively determine the oxygen pressure in interstitial (pericellular) spaces. Oxyphor G3 is a Pd-tetrabenzoporphyrin, encapsulated inside generation 2 poly-arylglycine (AG) dendrimer, and therefore is a true near infrared oxygen sensor, having a strong absorption band at 636nm and emission near 800nm. The periphery of the dendrimer is modified with oligoethylene glycol residues (Av. MW 350) to make the probe water soluble and biologically inert. Oxyphor G3 was injected along "tracks" in the tissue using a small needle (30gage or less) and remained in the pericellular space, allowing oxygen measurements for several hours with a single injection. The oxygen pressure distributions (histograms) were compared with those for Oxyphor G2 in the intravascular (blood plasma) space. In normal muscle, in the lower oxygen pressure region of the histograms (capillary bed) the oxygen pressure difference was small. At higher oxygen pressures in the histograms there were differences consistent with the presence of high flow vessels with oxygen pressures substantially above those of the surrounding interstitial space. In tumors, the oxygen pressures in the two spaces were similar but with large differences among tumors. In mice, anesthesia with ketamine plus xylazine markedly decreased oxygen pressures in the interstitial and intravascular spaces compared to awake or isoflurane anesthetized mice.

Oxygen pressures in the interstitial space of skeletal muscle and tumors in vivo. Publishing Authors By Initials

DF Wilson,WM Lee,S Makonnen,S Apreleva,SA Vinogradov,DF Wilson,WM Lee,S Makonnen,S Apreleva,SA Vinogradov,

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Oxygen pressures in the interstitial space of skeletal muscle and tumors in vivo. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Advances in experimental medicine and biology

VOLUME: 614

Page Numbers: 53-62

Journal Abbreviation: Adv. Exp. Med. Biol.

ISSN: 0065-2598

DAY: 22

MONTH: 02

YEAR: 2008

Oxygen pressures in the interstitial space of skeletal muscle and tumors in vivo. Information

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LANGUAGE: eng

NlmUniqueID: 121103

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Grant and Affiliation Information for Oxygen pressures in the interstitial space of skeletal muscle and tumors in vivo.

AFFILIATION: Department of Biochemistry and Biophysics, Medical School, University of Pennsylvania, Philadelphia, PA 19104, USA.

Country: United States

AGENCY: United States NCI

GRANT: U54 CA105008-01

ACRONYM: CA

MEDLINETA: Adv Exp Med Biol

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