Oxygen, nitric oxide and articular cartilage.

Oxygen, nitric oxide and articular cartilage. Research Abstract Details 

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Oxygen, nitric oxide and articular cartilage. Abstract Text:

B Fermor,S E Christensen,I Youn,J M Cernanec,C M Davies,J B Weinberg,

Molecular oxygen is required for the production of nitric oxide (NO), a pro-inflammatory mediator that is associated with osteoarthritis and rheumatoid arthritis. To date there has been little consideration of the role of oxygen tension in the regulation of nitric oxide production associated with arthritis. Oxygen tension may be particularly relevant to articular cartilage since it is avascular and therefore exists at a reduced oxygen tension. The superficial zone exists at approximately 6% O2, while the deep zone exists at less than 1% O2. Furthermore, oxygen tension can alter matrix synthesis, and the material properties of articular cartilage in vitro. The increase in nitric oxide associated with arthritis can be caused by pro-inflammatory cytokines and mechanical stress. Oxygen tension significantly alters endogenous NO production in articular cartilage, as well as the stimulation of NO in response to both mechanical loading and pro-inflammatory cytokines. Mechanical loading and pro-inflammatory cytokines also increase the production of prostaglandin E2 (PGE2). There is a complex interaction between NO and PGE2, and oxygen tension can alter this interaction. These findings suggest that the relatively low levels of oxygen within the joint may have significant influences on the metabolic activity, and inflammatory response of cartilage as compared to ambient levels. A better understanding of the role of oxygen in the production of inflammatory mediators in response to mechanical loading, or pro-inflammatory cytokines, may aid in the development of strategies for therapeutic intervention in arthritis.

Oxygen, nitric oxide and articular cartilage. Publishing Authors By Initials

B Fermor,SE Christensen,I Youn,JM Cernanec,CM Davies,JB Weinberg,

For similar animals: chordata: vertebrates: mammals: artiodactyla: swine research abstracts see: animals: chordata: vertebrates: mammals: artiodactyla: swine research

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Oxygen, nitric oxide and articular cartilage. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: European cells & materials

VOLUME: 13

Page Numbers: 56-65; discussion 65

Journal Abbreviation:

ISSN: 1473-2262

DAY: 11

MONTH: 04

YEAR: 2007

Oxygen, nitric oxide and articular cartilage. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100973416

Oxygen, nitric oxide and articular cartilage. Keywords Mesh Terms:

KEYWORDS: Swine

MESH TERMS: physiology

Chemical & Substance for Abstract: Oxygen, nitric oxide and articular cartilage. Information

Substance Name: Oxygen

Registry Number: 7782-44-7

Grant and Affiliation Information for Oxygen, nitric oxide and articular cartilage.

AFFILIATION: Department of Surgery, Division of Orthopaedic Surgery, Duke University Medical Center, Durham, NC 27710, USA. bfer@duke.edu

Country: Scotland

AGENCY: United States NIAMS

GRANT: AR 50245

ACRONYM: AR

MEDLINETA: Eur Cell Mater

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