Oxygen exchange in muscle of young and old rats: muscle-vascular-pulmonary coupling.

Oxygen exchange in muscle of young and old rats: muscle-vascular-pulmonary coupling. Research Abstract Details 

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Oxygen exchange in muscle of young and old rats: muscle-vascular-pulmonary coupling. Abstract Text:

David C Poole,Leonardo F Ferreira,

Sustained performance of muscular exercise is contingent upon increasing muscle O(2) delivery (Qo2; the product of blood flow and arterial O(2) content, i.e. Q X Cao2) and utilization (Vo2m ) rapidly at exercise onset and sustaining necessary conductive and diffusive O(2) fluxes throughout exercise. A tight co-ordination of pulmonary, cardiovascular and muscle system responses is therefore required to prevent muscle microvascular O(2) pressures (P(mvO(2))) from falling to levels that impair blood-muscle O(2) exchange and/or impact metabolic control and reduce exercise tolerance. Microvascular O(2) pressures are determined by the balance between and Qo2 and Vo2m, and emerging evidence indicates that this balance is regulated differently across muscle fibre types and also in aged muscle. Moreover, disease states such as diabetes (type I and II) and chronic heart failure (CHF) also impact P(mvO(2)). This brief review primarily examines evidence obtained in animals that ageing: (1) redistributes exercising away from highly oxidative muscles and muscle fibres; (2) alters muscle capillary haemodynamics; and (3) reduces the O(2) pressure head within the microcirculation (P(mvO(2))) that serves to facilitate blood-muscle O(2) transfer. In many respects, these alterations found in healthy ageing animals bear a striking resemblance to those present in some chronic diseases (e.g. diabetes, CHF) and may help explain the compromised exercise tolerance present in aged individuals. Putative mechanistic insights are explored within the context of current knowledge and future investigative approaches.

Oxygen exchange in muscle of young and old rats: muscle-vascular-pulmonary coupling. Publishing Authors By Initials

DC Poole,LF Ferreira,

For similar circulatory and respiratory physiology: respiratory physiology research abstracts see: circulatory and respiratory physiology: respiratory physiology research

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Oxygen exchange in muscle of young and old rats: muscle-vascular-pulmonary coupling. Journal Published:

PUBLICATION TYPE: Review

Journal: Experimental physiology

VOLUME: 92

Page Numbers: 341-6

Journal Abbreviation: Exp. Physiol.

ISSN: 0958-0670

DAY: 21

MONTH: 12

YEAR: 2006

Oxygen exchange in muscle of young and old rats: muscle-vascular-pulmonary coupling. Information

Number of References: 34

LANGUAGE: eng

NlmUniqueID: 9002940

Oxygen exchange in muscle of young and old rats: muscle-vascular-pulmonary coupling. Keywords Mesh Terms:

KEYWORDS: Respiratory Physiology

MESH TERMS: metabolism

Chemical & Substance for Abstract: Oxygen exchange in muscle of young and old rats: muscle-vascular-pulmonary coupling. Information

Substance Name: Oxygen

Registry Number: 7782-44-7

Grant and Affiliation Information for Oxygen exchange in muscle of young and old rats: muscle-vascular-pulmonary coupling.

AFFILIATION: Department of Anatomy and Physiology, Kansas State University, Manhattan, KS 66506, USA. poole@vet.ksu.edu

Country: England

AGENCY: United States NHLBI

GRANT: HL-50306

ACRONYM: HL

MEDLINETA: Exp Physiol

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