Oxidized phosphatidylcholine is a marker for neuroinflammation in multiple sclerosis brain.

Oxidized phosphatidylcholine is a marker for neuroinflammation in multiple sclerosis brain. Research Abstract Details 

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Oxidized phosphatidylcholine is a marker for neuroinflammation in multiple sclerosis brain. Abstract Text:

J Qin,R Goswami,R Balabanov,G Dawson,

Multiple sclerosis (MS) is a common autoimmune neurodegenerative disease of unknown cause, which results in inflammation and plaques of demyelination in brain and eventual axonal degeneration. We report the novel presence of oxidized phosphatidylcholine [1-palmitoyl-2-(5'-oxo)valeryl-sn-glycero-3-phosphorylcholine (POVPC)], a lipid associated with inflammatory diseases such as atherosclerosis and lung disease, in the brain of MS patients. The OxPC epitope was detected by Western blotting with the E06 monoclonal antibody. E06-positive lipid was present in the highest amounts in MS plaques, which also showed evidence of low-molecular-weight (15-kDa) OxPC-modified protein. E06 reactivity did not change with post-mortem interval, and E06-positive lipids were largely absent from control tissue. We then used a second monoclonal antibody (AB1-2, which recognizes the E06/T15 idiotype and therefore detects the presence of antibody to OxPC) to show that MS brain samples were strongly positive for the 50-kDa antibody heavy chain. We also showed that isoelectric focussing of the oligoclonal IgG characteristic of MS revealed some immunoglobulin bands that Western blotted with the AB1-2 antibody. Spinal cords from mice induced to undergo experimental allergic encephalomyelitis (EAE) also showed strong AB1-2 reactivity by both immunocytochemistry and Western blot analysis. We therefore conclude that we can detect both OxPC and 15-kDa protein modified by OxPC and the antibody to the antibody to OxPC (antiidiotype) in pathological tissue and suggest that this could play a role in the progression of MS.

Oxidized phosphatidylcholine is a marker for neuroinflammation in multiple sclerosis brain. Publishing Authors By Initials

J Qin,R Goswami,R Balabanov,G Dawson,

For similar nervous system: central nervous system: spinal cord research abstracts see: nervous system: central nervous system: spinal cord research

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Oxidized phosphatidylcholine is a marker for neuroinflammation in multiple sclerosis brain. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of neuroscience research

VOLUME: 85

Page Numbers: 977-84

Journal Abbreviation: J. Neurosci. Res.

ISSN: 0360-4012

DAY: 3

MONTH: Apr

YEAR: 2007

Oxidized phosphatidylcholine is a marker for neuroinflammation in multiple sclerosis brain. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7600111

Oxidized phosphatidylcholine is a marker for neuroinflammation in multiple sclerosis brain. Keywords Mesh Terms:

KEYWORDS: Spinal Cord

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Oxidized phosphatidylcholine is a marker for neuroinflammation in multiple sclerosis brain. Information

Substance Name: Phospholipid Ethers

Registry Number: 0

Grant and Affiliation Information for Oxidized phosphatidylcholine is a marker for neuroinflammation in multiple sclerosis brain.

AFFILIATION: Department of Pediatrics, University of Chicago, Chicago, Illinois, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS-36866

ACRONYM: NS

MEDLINETA: J Neurosci Res

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