Oxidized lipids: the two faces of vascular inflammation.

Oxidized lipids: the two faces of vascular inflammation. Research Abstract Details 

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Oxidized lipids: the two faces of vascular inflammation. Abstract Text:

Konstantin G Birukov,

Elevated plasma levels of low-density lipoprotein and generation of oxidized low-density lipoprotein have been directly associated with the pathogenesis of atherosclerosis, and lipid oxidation products have been directly linked with induction and propagation of monocytic subendothelial accumulation and other inflammatory reactions associated with chronic vascular inflammation. However, accumulating data suggest that oxidized lipids may also exhibit anti-inflammatory potential and serve as potent inhibitors of nuclear factor-kappaB-dependent proinflammatory cascade. In addition, we have characterized a group of bioactive components of oxidized phospholipids with barrier-protective effects towards endothelial cells in the models of agonist-induced endothelial permeability and lipopolysaccharide-induced lung dysfunction. This review discusses the role of oxidized lipids in the progression of atherosclerosis as well as the important anti-inflammatory effects of oxidized phospholipids and their potential role in the modulation of vascular barrier integrity.

Oxidized lipids: the two faces of vascular inflammation. Publishing Authors By Initials

KG Birukov,

For similar cardiovascular diseases: vascular diseases research abstracts see: cardiovascular diseases: vascular diseases research

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Oxidized lipids: the two faces of vascular inflammation. Journal Published:

PUBLICATION TYPE: Review

Journal: Current atherosclerosis reports

VOLUME: 8

Page Numbers: 223-31

Journal Abbreviation:

ISSN: 1523-3804

DAY: 3

MONTH: May

YEAR: 2006

Oxidized lipids: the two faces of vascular inflammation. Information

Number of References: 50

LANGUAGE: eng

NlmUniqueID: 100897685

Oxidized lipids: the two faces of vascular inflammation. Keywords Mesh Terms:

KEYWORDS: Vascular Diseases

MESH TERMS: pathology

Chemical & Substance for Abstract: Oxidized lipids: the two faces of vascular inflammation. Information

Substance Name: Oxygen

Registry Number: 7782-44-7

Grant and Affiliation Information for Oxidized lipids: the two faces of vascular inflammation.

AFFILIATION: Department of Medicine, University of Chicago, 929 East 57th Street, W410, Chicago, IL 60637, USA. kbirukov@medicine.bsd.uchicago.edu

Country: United States

AGENCY: United States NHLBI

GRANT: HL 076259

ACRONYM: HL

MEDLINETA: Curr Atheroscler Rep

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