Oxidative stress markers are associated with persistent atrial fibrillation.

Oxidative stress markers are associated with persistent atrial fibrillation. Research Abstract Details 

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Oxidative stress markers are associated with persistent atrial fibrillation. Abstract Text:

Robert B Neuman,Heather L Bloom,Irfan Shukrullah,Lyndsey A Darrow,David Kleinbaum,Dean P Jones,Samuel C Dudley,

BACKGROUND: Atrial fibrillation (AF) has been associated with myocardial oxidative stress, and antioxidant agents have demonstrated antiarrhythmic benefit in humans. We compared serum markers of oxidation and associated inflammation in individuals with or without AF. METHODS: Serum markers of oxidative stress and inflammation were compared in a cross-sectional, case-control design study of 40 male individuals, with or without persistent or permanent AF, who were matched for age, sex, diabetes, and smoking status, known confounding variables for the measurement of oxidative stress. We used derivatives of reactive oxidative metabolites (DROMs) and ratios of oxidized to reduced glutathione (E(h) GSH) and cysteine (E(h) CySH) to quantify oxidative stress. We also measured inflammatory markers, including high-sensitivity C-reactive protein, interleukins 1beta and 6, and tumor necrosis factor alpha. RESULTS: Univariate, conditional logistical regression analysis showed that oxidative stress but not inflammatory markers were statistically associated with AF (P <0.05). The increase in the odds ratios for AF for E(h) GSH, E(h) CySH, and DROMs were 6.1 (95% CI, 1.3-28.3; P = 0.02), 13.6 (95% CI, 2.5-74.1; P = 0.01), and 15.9 (95% CI, 1.7-153.9; P = 0.02), respectively. There was a stronger correlation between E(h) GSH and E(h) CySH (r = 0.66) than between E(h) GSH and DROMs (r = 0.41). In multivariate analysis corrected for statins and other AF risk factors differing between the groups, the association of AF and oxidative stress remained significant. CONCLUSIONS: These data suggest that oxidative stress markers may have predictive value in AF management.

Oxidative stress markers are associated with persistent atrial fibrillation. Publishing Authors By Initials

RB Neuman,HL Bloom,I Shukrullah,LA Darrow,D Kleinbaum,DP Jones,SC Dudley,

For similar peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research

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Oxidative stress markers are associated with persistent atrial fibrillation. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Clinical chemistry

VOLUME: 53

Page Numbers: 1652-7

Journal Abbreviation: Clin. Chem.

ISSN: 0009-9147

DAY: 28

MONTH: 06

YEAR: 2007

Oxidative stress markers are associated with persistent atrial fibrillation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9421549

Oxidative stress markers are associated with persistent atrial fibrillation. Keywords Mesh Terms:

KEYWORDS: Tumor Necrosis Factor-alpha

MESH TERMS: blood

Chemical & Substance for Abstract: Oxidative stress markers are associated with persistent atrial fibrillation. Information

Substance Name: C-Reactive Protein

Registry Number: 9007-41-4

Grant and Affiliation Information for Oxidative stress markers are associated with persistent atrial fibrillation.

AFFILIATION: Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL77398

ACRONYM: HL

MEDLINETA: Clin Chem

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