Oxidative stress during acute FIV infection in cats.

Oxidative stress during acute FIV infection in cats. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Oxidative stress during acute FIV infection in cats. Abstract Text:

Craig Webb,Tracy Lehman,Kelly McCord,Paul Avery,Steven Dow,

Oxidative stress is thought to contribute to the pathogenesis of HIV infection in humans. For example, CD4(+) T cells are particularly affected in HIV patients and oxidative stress may also contribute to impairment of neutrophil function in HIV/AIDS patients. Since cats infected with FIV develop many of the same immunological abnormalites as HIV-infected humans, we investigated effects of acute FIV infection on oxidative stress in cats. Cats were infected with a pathogenic strain of FIV and viral load, changes in neutrophil number, total blood glutathione, malondiadehye, antioxidant enzyme concentrations, and reduced glutathione (GSH) concentration in leukocytes were measured sequentially during the first 16 weeks of infection. We found that superoxide dismutase and glutathione peroxidase concentrations in whole blood increased significantly during acute FIV infection. In addition, neutrophil numbers increased significantly during this time period, though their intracellular GSH concentrations did not change. In contrast, the numbers of CD4(+) T cells decreased significantly and their intracellular GSH concentration increased significantly, while intracellular GSH concentrations were unchanged in CD8(+) T cells. However, by 16 weeks of infection, many of the abnormalities in oxidative balance had stabilized or returned to pre-inoculation values. These results suggest that acute infection with FIV causes oxidative stress in cats and that CD4(+) T cells appear to be preferentially affected. Further studies are required to determine whether early treatment with anti-oxidants may help ameliorate the decline in CD4(+) T cell number and function associated with acute FIV infection in cats.

Oxidative stress during acute FIV infection in cats. Publishing Authors By Initials

C Webb,T Lehman,K McCord,P Avery,S Dow,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Oxidative stress during acute FIV infection in cats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Veterinary immunology and immunopathology

VOLUME: 122

Page Numbers: 16-24

Journal Abbreviation: Vet. Immunol. Immunopathol.

ISSN: 0165-2427

DAY: 13

MONTH: 11

YEAR: 2007

Oxidative stress during acute FIV infection in cats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8002006

Oxidative stress during acute FIV infection in cats. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Oxidative stress during acute FIV infection in cats. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Oxidative stress during acute FIV infection in cats.

AFFILIATION: Department of Clinical Sciences, Colorado State University, Ft. Collins, CO 80523, USA.

Country: Netherlands

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Vet Immunol Immunopathol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Oxidative stress during acute FIV infection in cats Related Publications

• Action potentials of cerebellar cortex in response to local electrical stimulation.
• Carbon monoxide exposure on denali: comparing the 2004 and 2005 climbing seasons.
• Complementary global maps for orientation coding in upper and lower layers of the monkey's foveal striate cortex.
• Continuous low-dose oral chemotherapy for adjuvant therapy of splenic hemangiosarcoma in dogs.
• Corticotropin releasing hormone modulates endotoxin-induced inflammatory cytokine expression in human trophoblast cells.
• Diarrheal disease control studies; conical net for collecting flies.
• Diversification of the Function of Cell-to-Cell Signaling in Regulation of Virulence Within Plant Pathogenic Xanthomonads.
• EXTRINSIC REGULATORY MECHANISMS OF SEIZURE ACTIVITY.
• Evaluation of a novel tumor vaccine in dogs with hemangiosarcoma.
• Evaluation of a xenogeneic VEGF vaccine in dogs with soft tissue sarcoma.
• Excitability of skeletal muscle during development, denervation, and tissue culture.
• Foveal tracking cells in the superior temporal sulcus of the macaque monkey.
• Indications for steroid anaesthesia.
• Infants' early ability to segment the conversational speech signal predicts later language development: a retrospective analysis.
• Integrative physiology, functional genomics and the phenotype gap: a guide for comparative physiologists.
• Interspecies signalling via the Stenotrophomonas maltophilia diffusible signal factor influences biofilm formation and polymyxin tolerance in Pseudomonas aeruginosa.
• Intradural chordoma.
• Liposome-nucleic acid immunotherapeutics.
• Mefloquine-induced disruption of calcium homeostasis in Mammalian cells is similar to that induced by ionomycin.
• Neutrophil function in septic dogs.
• Oxidative stress during acute FIV infection in cats.
• Permanent transvenous dual-chamber pacing using the coronary sinus in a patient with a mechanical prosthetic tricuspid valve.
• Stance dependence of automatic postural adjustments in humans.
• Sustained generation of tissue dendritic cells from cats using organ stromal cell cultures.
• The effect of prolonged veno-arterial pumping on the circulation of the dog.
• The establishment clause argument for choice.
• Treatment of cerebral palsy; clinical study in use of d-tubocurarine in peanut oil and myricin.
• Use of FoxP3 expression to identify regulatory T cells in healthy dogs and dogs with cancer.
• Use of radium in treatment of hypertrophic lymphoid tissue in the nasopharynx.
• Vaccination with liposome--DNA complexes elicits enhanced antitumor immunity.