Oxidative stress, chronic disease, and muscle wasting.

Oxidative stress, chronic disease, and muscle wasting. Research Abstract Details 

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Oxidative stress, chronic disease, and muscle wasting. Abstract Text:

Jennifer S Moylan,Michael B Reid,

Underlying the pathogenesis of chronic disease is the state of oxidative stress. Oxidative stress is an imbalance in oxidant and antioxidant levels. If an overproduction of oxidants overwhelms the antioxidant defenses, oxidative damage of cells, tissues, and organs ensues. In some cases, oxidative stress is assigned a causal role in disease pathogenesis, whereas in others the link is less certain. Along with underlying oxidative stress, chronic disease is often accompanied by muscle wasting. It has been hypothesized that catabolic programs leading to muscle wasting are mediated by oxidative stress. In cases where disease is localized to the muscle, this concept is easy to appreciate. Transmission of oxidative stress from diseased remote organs to skeletal muscle is thought to be mediated by humoral factors such as inflammatory cytokines. This review examines the relationship between oxidative stress, chronic disease, and muscle wasting, and the mechanisms by which oxidative stress acts as a catabolic signal.

Oxidative stress, chronic disease, and muscle wasting. Publishing Authors By Initials

JS Moylan,MB Reid,

For similar inorganic chemicals: free radicals: reactive oxygen species research abstracts see: inorganic chemicals: free radicals: reactive oxygen species research

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Oxidative stress, chronic disease, and muscle wasting. Journal Published:

PUBLICATION TYPE: Review

Journal: Muscle & nerve

VOLUME: 35

Page Numbers: 411-29

Journal Abbreviation:

ISSN: 0148-639X

DAY: 3

MONTH: Apr

YEAR: 2007

Oxidative stress, chronic disease, and muscle wasting. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7803146

Oxidative stress, chronic disease, and muscle wasting. Keywords Mesh Terms:

KEYWORDS: Reactive Oxygen Species

MESH TERMS: metabolism

Chemical & Substance for Abstract: Oxidative stress, chronic disease, and muscle wasting. Information

Substance Name: Nitric Oxide

Registry Number: 10102-43-9

Grant and Affiliation Information for Oxidative stress, chronic disease, and muscle wasting.

AFFILIATION: Department of Physiology, University of Kentucky, 800 Rose Street, Room MS-509, Lexington, Kentucky 40536-0298, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL59878

ACRONYM: HL

MEDLINETA: Muscle Nerve

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