Oxidative stress causes bone loss in estrogen-deficient mice through enhanced bone marrow dendritic cell activation.

Oxidative stress causes bone loss in estrogen-deficient mice through enhanced bone marrow dendritic cell activation. Research Abstract Details 

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Oxidative stress causes bone loss in estrogen-deficient mice through enhanced bone marrow dendritic cell activation. Abstract Text:

Francesco Grassi,Gianluca Tell,Michaela Robbie-Ryan,Yuhao Gao,Masakazu Terauchi,Xiaoying Yang,Milena Romanello,Dean P Jones,M Neale Weitzmann,Roberto Pacifici,

Increased production of tumor necrosis factor alpha (TNF) in the bone marrow (BM) in response to both oxidative stress and T cell activation contributes to the bone loss induced by estrogen deficiency, but it is presently unknown whether oxidative stress causes bone loss through T cells. Here we show that ovariectomy causes an accumulation in the BM of reactive oxygen species, which leads to increased production of TNF by activated T cells through up-regulation of the costimulatory molecule CD80 on dendritic cells. Accordingly, bone loss is prevented by treatment of ovariectomized mice with either antioxidants or CTLA4-Ig, an inhibitor of the CD80/CD28 pathway. In summary, reactive oxygen species accumulation in the BM is an upstream consequence of ovariectomy that leads to bone loss by activating T cells through enhanced activity of BM dendritic cells, and these findings suggest that the CD80/CD28 pathway may represent a therapeutic target for postmenopausal bone loss.

Oxidative stress causes bone loss in estrogen-deficient mice through enhanced bone marrow dendritic cell activation. Publishing Authors By Initials

F Grassi,G Tell,M Robbie-Ryan,Y Gao,M Terauchi,X Yang,M Romanello,DP Jones,MN Weitzmann,R Pacifici,

For similar peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research

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Oxidative stress causes bone loss in estrogen-deficient mice through enhanced bone marrow dendritic cell activation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 15087-92

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 11

MONTH: 09

YEAR: 2007

Oxidative stress causes bone loss in estrogen-deficient mice through enhanced bone marrow dendritic cell activation. Information

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LANGUAGE: eng

NlmUniqueID: 7505876

Oxidative stress causes bone loss in estrogen-deficient mice through enhanced bone marrow dendritic cell activation. Keywords Mesh Terms:

KEYWORDS: Tumor Necrosis Factor-alpha

MESH TERMS: metabolism

Chemical & Substance for Abstract: Oxidative stress causes bone loss in estrogen-deficient mice through enhanced bone marrow dendritic cell activation. Information

Substance Name: abatacept

Registry Number: 0

Grant and Affiliation Information for Oxidative stress causes bone loss in estrogen-deficient mice through enhanced bone marrow dendritic cell activation.

AFFILIATION: Division of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University, Atlanta, GA 30322, USA.

Country: United States

AGENCY: United States NIAMS

GRANT: P30-AR46031

ACRONYM: AR

MEDLINETA: Proc Natl Acad Sci U S A

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