Oxidative stress biology and cell injury during type 1 and type 2 diabetes mellitus.

Oxidative stress biology and cell injury during type 1 and type 2 diabetes mellitus. Research Abstract Details 

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Oxidative stress biology and cell injury during type 1 and type 2 diabetes mellitus. Abstract Text:

Kenneth Maiese,Simona Daniela Morhan,Zhao Zhong Chong,

Diabetes mellitus (DM) affects approximately 170 million individuals worldwide and is expected to alter the lives of at least 366 million individuals within a future span of 25 years. Of even greater concern is the premise that these projections are underestimated since they assume obesity levels will remain constant. Type 1 insulin-dependent DM accounts for only 5-10 percent of all diabetics but represents a highly significant health concern, since this disorder begins early in life and leads to long-term complications. In contrast, Type 2 DM is recognized as the etiology of over 80 percent of all diabetics and is dramatically increasing in incidence as a result of changes in human behavior and increased body mass index. Yet, the pathological consequences of these disorders that involve the both the neuronal and vascular systems are intimately linked through the pathways that mediate oxidative stress. Here we highlight some of the relevant oxidative pathways that determine insulin resistance through reactive oxygen species, mitochondrial dysfunction, uncoupling proteins, and endoplasmic reticulum stress. These pathways are ultimately linked to protein kinase B (Akt) and the insulin signaling pathways that determine the initial onset of glucose intolerance and the subsequent course to apoptotic cell injury. Through the elucidation of these targets, improvement in current strategies as well as the development of future clinical applications can move forward for both the prevention and treatment of Type 1 and Type 2 DM.

Oxidative stress biology and cell injury during type 1 and type 2 diabetes mellitus. Publishing Authors By Initials

K Maiese,SD Morhan,ZZ Chong,

For similar biochemical phenomena, metabolism, and nutrition: metabolism: oxidative stress research abstracts see: biochemical phenomena, metabolism, and nutrition: metabolism: oxidative stress research

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Oxidative stress biology and cell injury during type 1 and type 2 diabetes mellitus. Journal Published:

PUBLICATION TYPE: Review

Journal: Current neurovascular research

VOLUME: 4

Page Numbers: 63-71

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ISSN: 1567-2026

DAY: 3

MONTH: Feb

YEAR: 2007

Oxidative stress biology and cell injury during type 1 and type 2 diabetes mellitus. Information

Number of References: 130

LANGUAGE: eng

NlmUniqueID: 101208439

Oxidative stress biology and cell injury during type 1 and type 2 diabetes mellitus. Keywords Mesh Terms:

KEYWORDS: Oxidative Stress

MESH TERMS: physiology

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Grant and Affiliation Information for Oxidative stress biology and cell injury during type 1 and type 2 diabetes mellitus.

AFFILIATION: Department of Neurology, 8C-1 UHC, Wayne State University School of Medicine, 4201 St. Antoine, Detroit, MI 48201, USA. kmaiese@med.wayne.edu

Country: Netherlands

AGENCY: United States NIEHS

GRANT: P30 ES06639

ACRONYM: ES

MEDLINETA: Curr Neurovasc Res

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