Oxidative stress and impaired insulin secretion in type 2 diabetes.

Oxidative stress and impaired insulin secretion in type 2 diabetes. Research Abstract Details 

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Oxidative stress and impaired insulin secretion in type 2 diabetes. Abstract Text:

R Paul Robertson,

Molecular mechanisms involving oxidative stress have been increasingly implicated in the pathogenesis of type 2 diabetes. These implications have arisen from reports that glucolipotoxicity of the pancreatic islet and non-islet tissues can lead to deterioration of islet function and insulin sensitivity, as well as structural abnormalities in tissues adversely affected by diabetes. Co-incident with these changes are profound alterations in insulin gene expression, which involve greatly diminished levels of two transcription factors, MafA and Pdx-1.

Oxidative stress and impaired insulin secretion in type 2 diabetes. Publishing Authors By Initials

RP Robertson,

For similar inorganic chemicals: free radicals: reactive oxygen species research abstracts see: inorganic chemicals: free radicals: reactive oxygen species research

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Oxidative stress and impaired insulin secretion in type 2 diabetes. Journal Published:

PUBLICATION TYPE: Review

Journal: Current opinion in pharmacology

VOLUME: 6

Page Numbers: 615-9

Journal Abbreviation:

ISSN: 1471-4892

DAY: 10

MONTH: 10

YEAR: 2006

Oxidative stress and impaired insulin secretion in type 2 diabetes. Information

Number of References: 29

LANGUAGE: eng

NlmUniqueID: 100966133

Oxidative stress and impaired insulin secretion in type 2 diabetes. Keywords Mesh Terms:

KEYWORDS: Reactive Oxygen Species

MESH TERMS: metabolism

Chemical & Substance for Abstract: Oxidative stress and impaired insulin secretion in type 2 diabetes. Information

Substance Name: Insulin

Registry Number: 11061-68-0

Grant and Affiliation Information for Oxidative stress and impaired insulin secretion in type 2 diabetes.

AFFILIATION: Pacific Northwest Research Institute and the Departments of Medicine and Pharmacology, University of Washington, 720 Broadway, Seattle, WA 98122, USA. rpr@pnri.org <rpr@pnri.org>

Country: England

AGENCY: United States PHS

GRANT: R0-1 38325

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MEDLINETA: Curr Opin Pharmacol

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