[Oxidative stress and antioxidants]

[Oxidative stress and antioxidants] Research Abstract Details 

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[Oxidative stress and antioxidants] Abstract Text:

Oxidative stress is a metabolic state where the cellular oxidative reactions are out of control. Under such conditions superoxide (O2.-) may accumulate, leading to formation of the hydroxyl radical, OH.. This is a free radical that abstracts hydrogen from the double bonds of unsaturated fatty acids. The fatty acid will then become a free radical which reacts easily with oxygen to form a peroxyradical. This will in turn abstract hydrogen from another fatty acid, establishing a perpetuating oxidative chain reaction. This may lead to peroxidation of cellular functions. DNA, proteins and carbohydrates may be oxidized too. There is good evidence that oxidative stress may play a role in the pathogenesis of cancer, atherosclerosis, ischemic tissue damage and inflammatory diseases. Possibly antioxidants can be used to limit oxidative stress. Recent reports indicate that high intake of vitamin E is associated with reduced risk of coronary heart disease.

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[Oxidative stress and antioxidants] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Tidsskrift for den Norske lægeforening : tidsskrif

VOLUME: 114

Page Numbers: 328-30

Journal Abbreviation: Tidsskr. Nor. Laegeforen.

ISSN: 0029-2001

DAY: 30

MONTH: Jan

YEAR: 1994

[Oxidative stress and antioxidants] Information

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LANGUAGE: nor

NlmUniqueID: 413423

[Oxidative stress and antioxidants] Keywords Mesh Terms:

KEYWORDS: Oxidation-Reduction

MESH TERMS: prevention & control

Chemical & Substance for Abstract: [Oxidative stress and antioxidants] Information

Substance Name: Free Radicals

Registry Number: 0

Grant and Affiliation Information for [Oxidative stress and antioxidants]

AFFILIATION: Kvinneklinikken og Cellebiologisk laboratorium, Aker sykehus, Oslo.

Country: NORWAY

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MEDLINETA: Tidsskr Nor Laegeforen

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