Oxidation of peptides by methyl(trifluoromethyl)dioxirane: the protecting group matters.

Oxidation of peptides by methyl(trifluoromethyl)dioxirane: the protecting group matters. Research Abstract Details 

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Oxidation of peptides by methyl(trifluoromethyl)dioxirane: the protecting group matters. Abstract Text:

Maria Rosaria Rella,Paul G Williard,

Representative Boc-protected and acetyl-protected peptide methyl esters bearing alkyl side chains undergo effective oxidation using methyl(trifluoromethyl)dioxirane (1b) under mild conditions. We observe a protecting group dependency in the chemoselectivity displayed by the dioxirane 1b. N-Hydroxylation occurs in the case of the Boc-protected peptides, and side chain hydroxylation takes place in the case of acetyl-protected peptides. Both are attractive transformations since they yield derivatized peptides that serve as valuable synthons.

Oxidation of peptides by methyl(trifluoromethyl)dioxirane: the protecting group matters. Publishing Authors By Initials

MR Rella,PG Williard,

For similar peptides research abstracts see: peptides research

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Oxidation of peptides by methyl(trifluoromethyl)dioxirane: the protecting group matters. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of organic chemistry

VOLUME: 72

Page Numbers: 525-31

Journal Abbreviation: J. Org. Chem.

ISSN: 0022-3263

DAY: 19

MONTH: Jan

YEAR: 2007

Oxidation of peptides by methyl(trifluoromethyl)dioxirane: the protecting group matters. Information

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LANGUAGE: eng

NlmUniqueID: 2985193

Oxidation of peptides by methyl(trifluoromethyl)dioxirane: the protecting group matters. Keywords Mesh Terms:

KEYWORDS: Peptides

MESH TERMS: chemistry

Chemical & Substance for Abstract: Oxidation of peptides by methyl(trifluoromethyl)dioxirane: the protecting group matters. Information

Substance Name: Ethylene Oxide

Registry Number: 75-21-8

Grant and Affiliation Information for Oxidation of peptides by methyl(trifluoromethyl)dioxirane: the protecting group matters.

AFFILIATION: Department of Chemistry, Brown University, Providence, Rhode Island 02912, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM-35982

ACRONYM: GM

MEDLINETA: J Org Chem

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• Oxidation of peptides by methyl(trifluoromethyl)dioxirane: the protecting group matters.