Oxidation artifacts in the electrospray mass spectrometry of Abeta Peptide.

Oxidation artifacts in the electrospray mass spectrometry of Abeta Peptide. Research Abstract Details 

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Oxidation artifacts in the electrospray mass spectrometry of Abeta Peptide. Abstract Text:

Maolian Chen,Kelsey D Cook,

Gradual corrosion of stainless steel electrospray emitters under conditions of normal use generates surface irregularities that can promote electrical discharge. The increased emission current affects the electrochemical reactions associated with the spray process. When sampling the peptide Abeta(1-40), this is manifest by oxidation of methionine at position 35 to methionine sulfoxide. The resultant mass shift and reduced sensitivity can adversely affect H/D exchange experiments. These effects can be avoided by adding a redox buffer or (preferably) by repolishing the emitter, especially to a rounded geometry.

Oxidation artifacts in the electrospray mass spectrometry of Abeta Peptide. Publishing Authors By Initials

M Chen,KD Cook,

For similar natural sciences: chemistry: chemistry, physical: surface properties research abstracts see: natural sciences: chemistry: chemistry, physical: surface properties research

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Oxidation artifacts in the electrospray mass spectrometry of Abeta Peptide. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Analytical chemistry

VOLUME: 79

Page Numbers: 2031-6

Journal Abbreviation: Anal. Chem.

ISSN: 0003-2700

DAY: 24

MONTH: 01

YEAR: 2007

Oxidation artifacts in the electrospray mass spectrometry of Abeta Peptide. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370536

Oxidation artifacts in the electrospray mass spectrometry of Abeta Peptide. Keywords Mesh Terms:

KEYWORDS: Surface Properties

MESH TERMS: chemistry

Chemical & Substance for Abstract: Oxidation artifacts in the electrospray mass spectrometry of Abeta Peptide. Information

Substance Name: Oxygen

Registry Number: 7782-44-7

Grant and Affiliation Information for Oxidation artifacts in the electrospray mass spectrometry of Abeta Peptide.

AFFILIATION: Department of Chemistry, University of Tennessee, Knoxville, Tennessee 37996-1600.

Country: United States

AGENCY: United States NIA

GRANT: R01-AG18927

ACRONYM: AG

MEDLINETA: Anal Chem

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