[Oxaliplatin in combination with LV5FU2 for advanced/metastatic gastric cancer-a multicenter study]

[Oxaliplatin in combination with LV5FU2 for advanced/metastatic gastric cancer-a multicenter study] Research Abstract Details 

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[Oxaliplatin in combination with LV5FU2 for advanced/metastatic gastric cancer-a multicenter study] Abstract Text:

Mao-lin Jin,Qiang Chen,Feng-qi Cheng,Wei Chen,Li Chen,Liang-xi Pan,Yu-fei Yang,

OBJECTIVE: To evaluate the effects and safety of OXA-LV5FU2 regimen for patients with advanced/metastatic gastric cancer. METHODS: OXA 100 mg/m(2) i.v. 2hr d1, LV200 mg/m(2) i.v. 2hr followed by 5-Fu 400 mg/m(2) i.v. bolus and 5-Fu 600 mg/m(2) i.v. 22hr d1, 2 were given, and repeated every 2 weeks. Efficacy was evaluated at 4 cycles (8 weeks). RESULTS: Forty three patients have been entered into the study. Patients with primary tumor resected or non-resected were 17 and 26. The evaluable lesions were 26 primary lesions, 22 lymph node metastases, 12 liver metastases, 1 pancreas metastasis and 2 soft tissue metastases. Forty patients were evaluable for clinical response. Four patients achieved CR (10.0%), 13 PR (32.5%), ORR 42.5% (95% CI 27.2 - 57.8), 17 SD (42.5%) and 6 PD (15.0%). Overall response rate (ORR) for chemotherapy naive (1(st) line) and pretreated (2(nd) line) patients were 50.0% (14/28) and 25.0% (3/12), respectively. Median time to progress (mTTP) was 5 months and median overall survival (mOS) was 8 months. Forty-three patients were evaluable for toxicity, with Grade 3, 4 WHO toxicity of neutropenia in 7 patients (16.3%), thrombocytopenia in 3 patients (7.0%), nausea/vomiting in 1 patient (2.3%). There were no Grade 3, 4 peripheral neuropathy toxicity or any deaths during treatment. CONCLUSION: OXA-LV5FU2 is a high response regimen for advanced gastric cancer with mild toxicity, which can be practiced safely.

[Oxaliplatin in combination with LV5FU2 for advanced/metastatic gastric cancer-a multicenter study] Publishing Authors By Initials

ML Jin,Q Chen,FQ Cheng,W Chen,L Chen,LX Pan,YF Yang,

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[Oxaliplatin in combination with LV5FU2 for advanced/metastatic gastric cancer-a multicenter study] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua zhong liu za zhi [Chinese journal of onco

VOLUME: 25

Page Numbers: 172-4

Journal Abbreviation: Zhonghua Zhong Liu Za Zhi

ISSN: 0253-3766

DAY: 10

MONTH: Mar

YEAR: 2003

[Oxaliplatin in combination with LV5FU2 for advanced/metastatic gastric cancer-a multicenter study] Information

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LANGUAGE: chi

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AFFILIATION: Peking University School of Oncology, Beijing Cancer Hospital, Beijing Institute for Cancer Research, Beijing 100036, China.

Country: China

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MEDLINETA: Zhonghua Zhong Liu Za Zhi

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