Overweight and decreased baroreflex sensitivity as independent risk factors for hypertension in children, adolescents, and young adults.

Overweight and decreased baroreflex sensitivity as independent risk factors for hypertension in children, adolescents, and young adults. Research Abstract Details 

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Overweight and decreased baroreflex sensitivity as independent risk factors for hypertension in children, adolescents, and young adults. Abstract Text:

We studied the relationship between blood pressure (BP), body mass index (BMI, kg/m(2)) and baroreflex sensitivity (BRS, ms/mmHg) in adolescents. We examined 34 subjects aged 16.2+/-2.4 years who had repeatedly high causal BP (H) and 52 controls (C) aged 16.4+/-2.2 years. Forty-four C and 22 H were of normal weight (BMI between 19-23.9), and 8 C and 12 H were overweight (BMI between 24-30). Systolic BP was recorded beat-to-beat for 5 min (Finapres, controlled breathing 0.33 Hz). BRS was determined by the cross-spectral method. The predicting power of BMI and BRS for hypertension was evaluated by sensitivity, specificity, and receiver operating curve (ROC - plot of sensitivity versus specificity). H compared with C had lower BRS (p<0.01) and higher BMI (p<0.05). Multiple logistic regression analysis (p<0.001) revealed that a decreased BRS (p<0.05) and an increased BMI (p<0.01) were independently associated with an increased risk of hypertension. No correlation between BMI and BRS was found either in H or in C. Following optimal critical values by ROC, the sensitivity, specificity and area under ROC were determined for: BMI - 22.2 kg/m(2), 61.8 %, 69.2 %, 66.0 %; BRS - 7.1 ms/mmHg, 67.7 %, 69.2 %, 70.0 %; BMI and BRS - 0.439 a.u., 73.5 %, 82.7 %, and 77.3 %. Decreased BRS and overweight were found to be independent risk factors for hypertension.

Overweight and decreased baroreflex sensitivity as independent risk factors for hypertension in children, adolescents, and young adults. Publishing Authors By Initials

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Overweight and decreased baroreflex sensitivity as independent risk factors for hypertension in children, adolescents, and young adults. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Physiological research / Academia Scientiarum Bohe

VOLUME: 57

Page Numbers: 385-91

Journal Abbreviation: Physiol Res

ISSN: 0862-8408

DAY: 30

MONTH: 05

YEAR: 2007

Overweight and decreased baroreflex sensitivity as independent risk factors for hypertension in children, adolescents, and young adults. Information

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LANGUAGE: eng

NlmUniqueID: 9112413

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AFFILIATION: Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic. nhonziko@med.muni.cz.

Country: Czech Republic

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MEDLINETA: Physiol Res

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