Overview of protein phosphorylation.

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Overview of protein phosphorylation. Abstract Text:

B M Sefton,B M Sefton,

Phosphorylation is the most common and important mechanism of acute and reversible regulation of protein function. Studies of mammalian cells metabolically labeled with [(32)P]orthophosphate suggest that as many as one-third of all cellular proteins are covalently modified by protein phosphorylation. Protein phosphorylation has an important role in essentially all aspects of cell biology. Most polypeptide growth factors (platelet-derived growth factor and epidermal growth factor are among the best studied) and cytokines (e.g., interleukin 2, colony stimulating factor 1, and gamma-interferon) stimulate phosphorylation upon binding to their receptors. Induced phosphorylation in turn activates cytoplasmic protein kinases, such as Raf, the activators of the mitogen-activated protein (MAP) kinases SEK and MEK, the MAP kinases ERK, JNK, and p38, the Janus/JAK kinases, the p21 activated kinases (PAKs), and the phosphatidylinsoitil 3'-kinase-activated kinase, protein kinase B/Akt. Additionally, in all nucleated organisms, cell cycle progression is regulated at both the G1/S and the G2/M transitions by cyclin-dependent protein kinases. These kinases regulate the G1/S transition by the phosphorylation of cell cycle regulators such as Rb protein and the G2/M transition through the phosphorylation of nuclear lamins and histones.

Overview of protein phosphorylation. Publishing Authors By Initials

BM Sefton,BM Sefton,

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Overview of protein phosphorylation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Current protocols in cell biology / editorial boar

VOLUME: Chapter 14

Page Numbers: Unit14.1

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ISSN: 1934-2616

DAY: 29

MONTH: May

YEAR: 2001

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LANGUAGE: eng

NlmUniqueID: 101287856

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AFFILIATION: The Salk Institute, San Diego, California.

Country: United States

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MEDLINETA: Curr Protoc Cell Biol

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