Overlapping functions of argonaute proteins in patterning and morphogenesis of Drosophila embryos.

Overlapping functions of argonaute proteins in patterning and morphogenesis of Drosophila embryos. Research Abstract Details 

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Overlapping functions of argonaute proteins in patterning and morphogenesis of Drosophila embryos. Abstract Text:

Wibke J Meyer,Silke Schreiber,Yi Guo,Thorsten Volkmann,Michael A Welte,H Arno J ,

Argonaute proteins are essential components of the molecular machinery that drives RNA silencing. In Drosophila, different members of the Argonaute family of proteins have been assigned to distinct RNA silencing pathways. While Ago1 is required for microRNA function, Ago2 is a crucial component of the RNA-induced silencing complex in siRNA-triggered RNA interference. Drosophila Ago2 contains an unusual amino-terminus with two types of imperfect glutamine-rich repeats (GRRs) of unknown function. Here we show that the GRRs of Ago2 are essential for the normal function of the protein. Alleles with reduced numbers of GRRs cause specific disruptions in two morphogenetic processes associated with the midblastula transition: membrane growth and microtubule-based organelle transport. These defects do not appear to result from disruption of siRNA-dependent processes but rather suggest an interference of the mutant Ago2 proteins in an Ago1-dependent pathway. Using loss-of-function alleles, we further demonstrate that Ago1 and Ago2 act in a partially redundant manner to control the expression of the segment-polarity gene wingless in the early embryo. Our findings argue against a strict separation of Ago1 and Ago2 functions and suggest that these proteins act in concert to control key steps of the midblastula transition and of segmental patterning.

Overlapping functions of argonaute proteins in patterning and morphogenesis of Drosophila embryos. Publishing Authors By Initials

WJ Meyer,S Schreiber,Y Guo,T Volkmann,MA Welte,HA ,

For similar proteins: membrane proteins: receptors, cell surface: receptors, biogenic amine: receptors, catecholamine: receptors, dopamine: receptors, dopamine d1 research abstracts see: proteins: membrane proteins: receptors, cell surface: receptors, biogenic amine: receptors, catecholamine: receptors, dopamine: receptors, dopamine d1 research

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Overlapping functions of argonaute proteins in patterning and morphogenesis of Drosophila embryos. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: PLoS genetics

VOLUME: 2

Page Numbers: e134

Journal Abbreviation: PLoS Genet.

ISSN: 1553-7404

DAY: 13

MONTH: 07

YEAR: 2006

Overlapping functions of argonaute proteins in patterning and morphogenesis of Drosophila embryos. Information

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LANGUAGE: eng

NlmUniqueID: 101239074

Overlapping functions of argonaute proteins in patterning and morphogenesis of Drosophila embryos. Keywords Mesh Terms:

KEYWORDS: Receptors, Dopamine D1

MESH TERMS: physiology

Chemical & Substance for Abstract: Overlapping functions of argonaute proteins in patterning and morphogenesis of Drosophila embryos. Information

Substance Name: wingless protein, Drosophila

Registry Number: 117758-26-6

Grant and Affiliation Information for Overlapping functions of argonaute proteins in patterning and morphogenesis of Drosophila embryos.

AFFILIATION: Institut für Genetik, Heinrich-Heine Universität, Düsseldorf, Germany.

Country: United States

AGENCY: United States NCRR

GRANT: S10RR16780

ACRONYM: RR

MEDLINETA: PLoS Genet

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