Overlapping and distinct expression of progesterone receptors A and B in mouse uterus and mammary gland during the estrous cycle.

Overlapping and distinct expression of progesterone receptors A and B in mouse uterus and mammary gland during the estrous cycle. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Overlapping and distinct expression of progesterone receptors A and B in mouse uterus and mammary gland during the estrous cycle. Abstract Text:

In rodents, progesterone receptors (PRs) A and B have different and often nonoverlapping roles, and this study asked whether different activities of the PR proteins in mouse are related to differences in their expression in reproductive tissues. The individual expression of PRA and PRB was determined immunohistochemically in mammary gland and uterus during the estrous cycle or in response to endocrine manipulation. In the mammary gland, PRA and PRB were colocated in PR+ epithelial cells, with little change during the estrous cycle. In the uterus, PRA was not detected in luminal epithelium at any stage of the cycle, and PR+ luminal cells expressed only PRB. In the stroma and myometrium, PRA and PRB levels fluctuated with cyclical systemic hormone exposure. Observation of functional end points suggested that augmented stromal and/or myometrial PRA in proestrus inhibited estrogen receptor expression and epithelial proliferation. Colocation of PRA and PRB was hormonally regulated, and ovariectomy did not reproduce the expression of PRA and PRB in the uterus during the estrous cycle. Whereas PRB was the only PR in the luminal epithelium in cycling mice, ovariectomy restored PRA expression, resulting in PRA-PRB colocation. In stroma and myometrium, PRA and PRB colocated in PR+ cells, but ovariectomy reduced PRA levels more than PRB, resulting in PRB-only-expressing cells. This study has shown that nonoverlapping PRA and PRB expression in the uterus, in particular the lack of PRA, and expression of PRB only in the luminal epithelium throughout the estrous cycle, is likely to contribute to the distinct roles of PRA and PRB in the adult mouse.

Overlapping and distinct expression of progesterone receptors A and B in mouse uterus and mammary gland during the estrous cycle. Publishing Authors By Initials

For similar urogenital system: genitalia: genitalia, female: uterus research abstracts see: urogenital system: genitalia: genitalia, female: uterus research

PUBMED ID PMID:

MEDLINE DATE:

Overlapping and distinct expression of progesterone receptors A and B in mouse uterus and mammary gland during the estrous cycle. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Endocrinology

VOLUME: 147

Page Numbers: 5503-12

Journal Abbreviation: Endocrinology

ISSN: 0013-7227

DAY: 15

MONTH: 09

YEAR: 2006

Overlapping and distinct expression of progesterone receptors A and B in mouse uterus and mammary gland during the estrous cycle. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 375040

Overlapping and distinct expression of progesterone receptors A and B in mouse uterus and mammary gland during the estrous cycle. Keywords Mesh Terms:

KEYWORDS: Uterus

MESH TERMS: metabolism

Chemical & Substance for Abstract: Overlapping and distinct expression of progesterone receptors A and B in mouse uterus and mammary gland during the estrous cycle. Information

Substance Name: progesterone receptor B

Registry Number: 0

Grant and Affiliation Information for Overlapping and distinct expression of progesterone receptors A and B in mouse uterus and mammary gland during the estrous cycle.

AFFILIATION: Westmead Institute for Cancer Research, University of Sydney at the Westmead Millennium Institute, and Department of Gynecological Oncology, Westmead Hospital, New South Wales 2145, Australia. patricia_mote@wmi.usyd.edu.au

Country: United States

AGENCY: United States NICHD

GRANT: HD32007

ACRONYM: HD

MEDLINETA: Endocrinology

REFSOURCE: Endocrinology. 2006 Dec;147(12):5501-2

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Overlapping and distinct expression of progesterone receptors A and B in mouse uterus and mammary gland during the estrous cycle Related Publications

• A novel SET domain methyltransferase in yeast: Rkm2-dependent trimethylation of ribosomal protein L12ab at lysine 10.
• Alcohol and recreational drug use by HIV-seropositive homosexual men.
• An adsorption isotherm for the interaction of membrane-permeable hydrophobic ions with lipid vesicles.
• Autophagy and insulin/TOR signaling in Caenorhabditis elegans pcm-1 protein repair mutants.
• Chlamydia trachomatis major outer membrane protein epitopes expressed as fusions with LamB in an attenuated aro A strain of Salmonella typhimurium; their application as potential immunogens.
• Contrast-enhanced first-pass myocardial perfusion magnetic resonance imaging with parallel acquisition at 3.0 Tesla.
• Correlation between clinical severity in patients with Rett syndrome with a p.R168X or p.T158M MECP2 mutation, and the direction and degree of skewing of X-chromosome inactivation.
• Dissecting the anti-desmoglein autoreactive B cell repertoire in pemphigus vulgaris patients.
• Endogenous synthesis of coenzyme Q in eukaryotes.
• Estrogen receptor alpha positive breast tumors and breast cancer cell lines share similarities in their transcriptome data structures.
• Evaluating the discriminatory power of a computer-based system for assessing penetrating trauma on retrospective multi-center data.
• Functional selectivity of hallucinogenic phenethylamine and phenylisopropylamine derivatives at human 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors.
• High altitude medicine.
• Implementing the GEC-ESTRO Recommendations for Evaluation of OAR in Gynaecological Brachytherapy.
• In vivo analysis of chromosome condensation in Saccharomyces cerevisiae.
• Iron particles for noninvasive monitoring of bone marrow stromal cell engraftment into, and isolation of viable engrafted donor cells from, the heart.
• Lung cancer in systemic lupus erythematosus.
• Organizational climate and culture factors.
• Overlapping and distinct expression of progesterone receptors A and B in mouse uterus and mammary gland during the estrous cycle.
• PAT-1 (Slc26a6) is the predominant apical membrane Cl-/HCO3- exchanger in the upper villous epithelium of the murine duodenum.
• Predictors of fear of hypoglycemia in adolescents with type 1 diabetes and their parents.
• Recognition of age-damaged (R,S)-adenosyl-L-methionine by two methyltransferases in the yeast Saccharomyces cerevisiae.
• Reflections on the reproductive sciences in agriculture in the UK and US, ca. 1900-2000+.
• Reversible Watermarking Surviving JPEG Compression.
• Similar CD19 dysregulation in two autoantibody-associated autoimmune diseases suggests a shared mechanism of B-cell tolerance loss.
• Target-derived neurotrophins may influence the survival of adult retinal ganglion cells when local neurotrophic support is disrupted: Implications for glaucoma.
• The history of three scientific societies: the Society for the Study of Fertility (now the Society for Reproduction and Fertility) (Britain), the Société Française pour l'Etude de la Fertilité, and the Society for the Study of Reproduction (USA).
• The yjbEFGH locus in Escherichia coli K-12 is an operon encoding proteins involved in exopolysaccharide production.
• Towards the design of a generic systems architecture for remote patient monitoring.
• Yeast ribosomal/cytochrome c SET domain methyltransferase subfamily: identification of Rpl23ab methylation sites and recognition motifs.