Overexpression of two transcriptional factors, Kin28 and Pog1, suppresses the stress sensitivity caused by the rsp5 mutation in Saccharomyces cerevisiae.

Overexpression of two transcriptional factors, Kin28 and Pog1, suppresses the stress sensitivity caused by the rsp5 mutation in Saccharomyces cerevisiae. Research Abstract Details 

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Overexpression of two transcriptional factors, Kin28 and Pog1, suppresses the stress sensitivity caused by the rsp5 mutation in Saccharomyces cerevisiae. Abstract Text:

Mika Demae,Yoshinori Murata,Mirei Hisano,Yutaka Haitani,Jun Shima,Hiroshi Takagi,Mika Demae,Yoshinori Murata,Mirei Hisano,Yutaka Haitani,Jun Shima,Hiroshi Takagi,Mika Demae,Yoshinori Murata,Mirei Hisano,Yutaka Haitani,Jun Shima,Hiroshi Takagi,

Rsp5 is an essential and multi-functional E3 ubiquitin ligase in Saccharomyces cerevisiae. The Ala401Glu rsp5 mutant, which is hypersensitive to various stresses, was isolated previously. To understand the function of Rsp5 in stress responses, suppressor genes whose overexpression allows rsp5(A401E) cells to grow at a high temperature were screened. The KIN28 and POG1 genes, encoding a subunit of the transcription factor TFIIH and a putative transcriptional activator, respectively, were identified as multicopy suppressors of not only high temperature but also LiCl stresses. The overexpression of Kin28 and Pog1 in rsp5(A401E) cells led to an increase in the transcriptional level of some stress proteins when exposed to a temperature up-shift. Based on DNA microarray analysis under LiCl stress, it appears that the transcriptional level of some proteasome components is slightly increased in rsp5(A401E) cells overexpressing Kin28 or Pog1. These results suggest that the overexpression of Kin28 and Pog1 enhances the protein refolding and degradation pathways in rsp5(A401E) cells.

Overexpression of two transcriptional factors, Kin28 and Pog1, suppresses the stress sensitivity caused by the rsp5 mutation in Saccharomyces cerevisiae. Publishing Authors By Initials

M Demae,Y Murata,M Hisano,Y Haitani,J Shima,H Takagi,M Demae,Y Murata,M Hisano,Y Haitani,J Shima,H Takagi,M Demae,Y Murata,M Hisano,Y Haitani,J Shima,H Takagi,

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Overexpression of two transcriptional factors, Kin28 and Pog1, suppresses the stress sensitivity caused by the rsp5 mutation in Saccharomyces cerevisiae. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: FEMS microbiology letters

VOLUME: 277

Page Numbers: 70-8

Journal Abbreviation: FEMS Microbiol. Lett.

ISSN: 0378-1097

DAY: 7

MONTH: Dec

YEAR: 2007

Overexpression of two transcriptional factors, Kin28 and Pog1, suppresses the stress sensitivity caused by the rsp5 mutation in Saccharomyces cerevisiae. Information

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LANGUAGE: eng

NlmUniqueID: 7705721

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Grant and Affiliation Information for Overexpression of two transcriptional factors, Kin28 and Pog1, suppresses the stress sensitivity caused by the rsp5 mutation in Saccharomyces cerevisiae.

AFFILIATION: Department of Bioscience, Fukui Prefectural University, Eiheiji-cho, Fukui, Japan.

Country: England

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MEDLINETA: FEMS Microbiol Lett

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