Overexpression of the Rho-guanine nucleotide exchange factor ECT2 inhibits nuclear translocation of nuclear receptor CAR in the mouse liver.

Overexpression of the Rho-guanine nucleotide exchange factor ECT2 inhibits nuclear translocation of nuclear receptor CAR in the mouse liver. Research Abstract Details 

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Overexpression of the Rho-guanine nucleotide exchange factor ECT2 inhibits nuclear translocation of nuclear receptor CAR in the mouse liver. Abstract Text:

Fardin Hosseinpour,Yoav Timsit,Chika Koike,Kenji Matsui,Yukio Yamamoto,Rick Moore,Masahiko Negishi,Fardin Hosseinpour,Yoav Timsit,Chika Koike,Kenji Matsui,Yukio Yamamoto,Rick Moore,Masahiko Negishi,Fardin Hosseinpour,Yoav Timsit,Chika Koike,Kenji Matsui,Yukio Yamamoto,Rick Moore,Masahiko Negishi,

Various drugs such as phenobarbital (PB) trigger translocation of constitutive active/adrostane receptor (CAR) from the cytoplasm into the nucleus of mouse liver cells without directly binding to the receptor. We have now characterized the guanine nucleotide exchange factor epithelial cell-transforming gene 2 (ECT2) as a PB-inducible factor as well as a cellular signal that represses PB-triggered nuclear translocation of CAR. When CFP-tagged ECT2 was co-expressed with YFP-tagged CAR in the liver of Car(-/-) mice, ECT2 repressed CAR nuclear translocation. Coexpression of various deletion mutants delineated this repressive activity to the tandem Dbl homology/pleckstrin homology domains of ECT2 and to their cytosolic expression. CAR directly bound to the PH domain. Thus, ECT2 may comprise a part of the PB response signal regulating the intracellular trafficking of CAR.

Overexpression of the Rho-guanine nucleotide exchange factor ECT2 inhibits nuclear translocation of nuclear receptor CAR in the mouse liver. Publishing Authors By Initials

F Hosseinpour,Y Timsit,C Koike,K Matsui,Y Yamamoto,R Moore,M Negishi,F Hosseinpour,Y Timsit,C Koike,K Matsui,Y Yamamoto,R Moore,M Negishi,F Hosseinpour,Y Timsit,C Koike,K Matsui,Y Yamamoto,R Moore,M Negishi,

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Overexpression of the Rho-guanine nucleotide exchange factor ECT2 inhibits nuclear translocation of nuclear receptor CAR in the mouse liver. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: FEBS letters

VOLUME: 581

Page Numbers: 4937-42

Journal Abbreviation: FEBS Lett.

ISSN: 0014-5793

DAY: 21

MONTH: 09

YEAR: 2007

Overexpression of the Rho-guanine nucleotide exchange factor ECT2 inhibits nuclear translocation of nuclear receptor CAR in the mouse liver. Information

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LANGUAGE: eng

NlmUniqueID: 155157

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AFFILIATION: Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, United States.

Country: Netherlands

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MEDLINETA: FEBS Lett

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