Overexpression of RhoE has a prognostic value in non-small cell lung cancer.

Overexpression of RhoE has a prognostic value in non-small cell lung cancer. Research Abstract Details 

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Overexpression of RhoE has a prognostic value in non-small cell lung cancer. Abstract Text:

Cuiyan Zhang,Fang Zhou,Ning Li,Susheng Shi,Xiaoli Feng,Zhaoli Chen,Jie Hang,Bin Qiu,Baozhong Li,Sheng Chang,Junting Wan,Kang Shao,Xuezhong Xing,Xiaogang Tan,Zhen Wang,Meihua Xiong,Jie He,Cuiyan Zhang,Fang Zhou,Ning Li,Susheng Shi,Xiaoli Feng,Zhaoli Chen,Jie Hang,Bin Qiu,Baozhong Li,Sheng Chang,Junting Wan,Kang Shao,Xuezhong Xing,Xiaogang Tan,Zhen Wang,Meihua Xiong,Jie He,

BACKGROUND: Increasing evidence has suggested that RhoE plays an important role in carcinogenesis and progression. However, the correlation between RhoE expression and clinical outcome in lung cancer has not been investigated. METHODS: RhoE expression was detected by immunohistochemistry on tissue microarray containing samples from 115 patients with non-small cell lung cancer with a median follow-up of 54 months. RESULTS: RhoE was overexpressed in the cytoplasm of lung cancer cells compared with undetectable expression of RhoE in the adjacent nontumoral cells. Patients with RhoE-negative tumors had substantially longer cancer-related survival than did patients with RhoE-positive tumors. Multivariate analysis showed that RhoE overexpression was an independent marker for cancer-related survival in the entire population after adjusting for other prognostic factors. CONCLUSIONS: RhoE expression may serve as an unfavorable prognostic factor in patients with non-small cell lung cancer.

Overexpression of RhoE has a prognostic value in non-small cell lung cancer. Publishing Authors By Initials

C Zhang,F Zhou,N Li,S Shi,X Feng,Z Chen,J Hang,B Qiu,B Li,S Chang,J Wan,K Shao,X Xing,X Tan,Z Wang,M Xiong,J He,C Zhang,F Zhou,N Li,S Shi,X Feng,Z Chen,J Hang,B Qiu,B Li,S Chang,J Wan,K Shao,X Xing,X Tan,Z Wang,M Xiong,J He,

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Overexpression of RhoE has a prognostic value in non-small cell lung cancer. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Annals of surgical oncology

VOLUME: 14

Page Numbers: 2628-35

Journal Abbreviation: Ann. Surg. Oncol.

ISSN: 1068-9265

DAY: 25

MONTH: 05

YEAR: 2007

Overexpression of RhoE has a prognostic value in non-small cell lung cancer. Information

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LANGUAGE: eng

NlmUniqueID: 9420840

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AFFILIATION: Department of Thoracic Surgery, Peking Union Medical College, Chinese Academy of Medical Sciences, 100021, Beijing, China.

Country: United States

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MEDLINETA: Ann Surg Oncol

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