Overexpression of mitochondrial superoxide dismutase in mice protects the retina from diabetes-induced oxidative stress.

Overexpression of mitochondrial superoxide dismutase in mice protects the retina from diabetes-induced oxidative stress. Research Abstract Details 

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Overexpression of mitochondrial superoxide dismutase in mice protects the retina from diabetes-induced oxidative stress. Abstract Text:

Sushil K Jain,

The retina experiences mitochondrial dysfunction in diabetes, superoxide levels are elevated, and mitochondrial superoxide dismutase (MnSOD) activity is decreased. Inhibition of superoxide accumulation in diabetes prevents mitochondrial dysfunction, apoptosis of retinal capillary cells, and the development of retinal histopathology. The purpose of this study is to examine the effect of overexpression of MnSOD on oxidative stress, DNA damage, and nitrative stress in the retina of diabetic mice. After 7 weeks of diabetes in MnSOD overexpressing (hemizygous) mice (MnSOD-Tg) and in their age-matched nontransgenic mice, parameters of oxidative stress and nitrative stress were measured in the retina. Overexpression of MnSOD prevented diabetes-induced decreases in retinal GSH levels and the total antioxidant capacity. In the same retina, MnSOD overexpression also inhibited diabetes-induced increases in the levels of 8-OHdG and nitrotyrosine. This suggests that MnSOD could be implicated in the pathogenesis of retinopathy by protecting the retina from increased oxidative damage experienced in diabetic conditions. Thus, understanding how changes in mitochondrial function result in the development of diabetic retinopathy could help identify SOD mimics to inhibit its development.

Overexpression of mitochondrial superoxide dismutase in mice protects the retina from diabetes-induced oxidative stress. Publishing Authors By Initials

SK Jain,

For similar enzymes and coenzymes: enzymes: oxidoreductases: superoxide dismutase research abstracts see: enzymes and coenzymes: enzymes: oxidoreductases: superoxide dismutase research

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MEDLINE DATE:

Overexpression of mitochondrial superoxide dismutase in mice protects the retina from diabetes-induced oxidative stress. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Free radical biology & medicine

VOLUME: 41

Page Numbers: 1191-6

Journal Abbreviation: Free Radic. Biol. Med.

ISSN: 0891-5849

DAY: 6

MONTH: 02

YEAR: 2006

Overexpression of mitochondrial superoxide dismutase in mice protects the retina from diabetes-induced oxidative stress. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8709159

Overexpression of mitochondrial superoxide dismutase in mice protects the retina from diabetes-induced oxidative stress. Keywords Mesh Terms:

KEYWORDS: Superoxide Dismutase

MESH TERMS: metabolism

Chemical & Substance for Abstract: Overexpression of mitochondrial superoxide dismutase in mice protects the retina from diabetes-induced oxidative stress. Information

Substance Name: Superoxide Dismutase

Registry Number: EC 1.15.1.1

Grant and Affiliation Information for Overexpression of mitochondrial superoxide dismutase in mice protects the retina from diabetes-induced oxidative stress.

AFFILIATION: Department of Ophthalmology, Kresge Eye Institute, Wayne State University, Detroit, MI 48201, USA. rkowluru@med.wayne.edu

Country: United States

AGENCY: United States NIEHS

GRANT: P30 ES 006639

ACRONYM: ES

MEDLINETA: Free Radic Biol Med

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