Overexpression of hMSH2 and hMLH1 protein in certain gastric cancers and their surrounding mucosae.

Overexpression of hMSH2 and hMLH1 protein in certain gastric cancers and their surrounding mucosae. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Overexpression of hMSH2 and hMLH1 protein in certain gastric cancers and their surrounding mucosae. Abstract Text:

Mei Li,Lina Liu,Zhaohui Wang,Lihong Wang,Zhimin Liu,Guowang Xu,Shen Lu,Mei Li,Lina Liu,Zhaohui Wang,Lihong Wang,Zhimin Liu,Guowang Xu,Shen Lu,

Mismatch repair (MMR) deficiency is closely related to oncogenesis, which is usually accompanied with the loss of expression of hMSH2 and/or hMLH1. These two proteins are detected in many gastric cancers (GCs), and even their overexpression have been reported in certain other cancers. We studied the protein expression levels of MMR (hMSH2 and hMLH1), PCNA and Ki67 in the cancers and surrounding mucosae (SMs) collected from the patients with GC and gastric mucosa samples from non-cancer patients (NCMs), using immunohistochemistry. Our results demonstrated that the positive MMR protein expression levels were 69.1% (132/191), 33.1% (44/133) and 7.1% (3/42) in GCs, SMs and NCMs, respectively (P<0.001); the positive PCNA protein expression levels were 92.1% (176/191), 75.9% (101/133) and 23.8% (10/42), respectively (P<0.001); the positive Ki67 protein expression levels were 79.1% (68/86), 29.2% (21/72) and 45.2% (19/42), respectively (P<0.001). In addition, the MMR protein expression significantly correlated to the level of PCNA protein expression (rs=0.170, P=0.019), but not to the level of Ki67 protein expression in GCs. Notably, the overexpression of MMR protein was not correlated to either PCNA or Ki67 protein expression in SMs and NCMs. These results support the evidence that MMR protein expression may increase prior to gastric cancer occurrence, and in a view of early diagnosis, the detection of MMR protein by IHC may be helpful as a marker in early prediction of gastric cancer.

Overexpression of hMSH2 and hMLH1 protein in certain gastric cancers and their surrounding mucosae. Publishing Authors By Initials

M Li,L Liu,Z Wang,L Wang,Z Liu,G Xu,S Lu,M Li,L Liu,Z Wang,L Wang,Z Liu,G Xu,S Lu,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Overexpression of hMSH2 and hMLH1 protein in certain gastric cancers and their surrounding mucosae. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Oncology reports

VOLUME: 19

Page Numbers: 401-6

Journal Abbreviation: Oncol. Rep.

ISSN: 1021-335X

DAY: 18

MONTH: Feb

YEAR: 2008

Overexpression of hMSH2 and hMLH1 protein in certain gastric cancers and their surrounding mucosae. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9422756

Overexpression of hMSH2 and hMLH1 protein in certain gastric cancers and their surrounding mucosae. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Overexpression of hMSH2 and hMLH1 protein in certain gastric cancers and their surrounding mucosae. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Overexpression of hMSH2 and hMLH1 protein in certain gastric cancers and their surrounding mucosae.

AFFILIATION: Laboratory Center, The Second Affiliated Hospital of Dalian Medical University, Dalian 116027, Liaoning Province, P.R. China.

Country: Greece

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Oncol Rep

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Overexpression of hMSH2 and hMLH1 protein in certain gastric cancers and their surrounding mucosae Related Publications

• Educational diagnosis of self-management behaviors of parents with asthmatic children by triangulation based on PRECEDE-PROCEED model in Taiwan.
• Effect of transforming growth factor-beta(2) on extracellular matrix synthesis in bovine trabecular meshwork cells.
• Influence of abnormal cervical pap smear undertaken during pregnancy to the outcome of the pregnancy.
• WT1 downregulation during K562 cell differentiation and apoptosis induced by bufalin.
• [Analysis of three-dimensional microstructure of poly(lactide-co-glycolide) scaffolds made by mild heating under high pressure]
• [Changes in plasma levels of adrenomedullin and cyclic adenosine monophosphate and their interrelation in patients with chronic heart failure]
• [Clinical significance of serum troponin I in patients with acute left heart failure]
• [Cloning and expression of the gene of recombinant augmenter of liver regeneration in yeast]
• [Collection, processing and cryopreservation of placental cord blood hematopoietic stem cells]
• [Construction of pcDNA3.1AM and expression of adrenomedullin in mammalian cells]
• [Cytogenetic analysis on 1058 cases of acute nonlymphocytic leukemia]
• [Determination of domoic acid in water and aquatic animals by high performance liquid chromatography]
• [Diagnosing achondroplasia by single cell nested-PCR]
• [Different effects of acetylcholine on the action potential and force contraction in guinea pig atrial and ventricular myocardium]
• [Effect of tumor necrosis factor-alpha on differentiation of mesencephalic neural stem cells and proliferation of oligodendrocytes in the rat]
• [Heterogeneity of action potential and ion currents in the left ventricular myocytes of the rabbit]
• [Human leukocyte antigen mismatched hemopietic stem cell transplants for the treatment of leukemia]
• [Human peripheral blood monocyte derived dendritic cell culture and mature regulation]
• [Inhibition of proliferation and induction of apoptosis by simvastatin in K562 leukemic cell line]
• [MK-801 suppresses dynorphin A (1-17)-induced facilitation of nociceptive responses to formalin in rats]
• [Molecular cytogenetic detection of partial chromosome 13q trisomy and its relation with the clinical features of tortilcollis]
• [Non-Hodgkin's lymphoma in the lacrimal gland: report of one case]
• [Reactive oxygen species and mitochondrial KATP-sensitive channels mediated cardioprotection induced by TNF-alpha during hypoxia and reoxygenation]
• [Relationship between soluble Fas ligand levels and complications after allogeneic bone marrow transplantation]
• [Relationship of I/D polymorphism of angiotensin converting enzyme gene with hypertension in Xinjiang Kazakh isolated group]
• [Sequencing of the glyceraldehyde-3-phosphate dehydrogenase gene from Plasmodium falciparum strain FCC1/HN]
• [Study on defibrinogenasing enhancing the thrombolytic effect of urokinase on acute myocardial infarction]
• [Study on preparation of beta-cyclodextrin inclusion compound of volatile oil from Aucklandia lappa]
• [The determination of F-, Cl-, NO3- and SO(4)2- in the total suspended particles in air by ion chromatography]
• [Treatment of primary trauma in the brainstem: analysis of 126 cases]