Over-inhibition: a model for developmental intellectual disability.

Over-inhibition: a model for developmental intellectual disability. Research Abstract Details 

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Over-inhibition: a model for developmental intellectual disability. Abstract Text:

Fabian Fernandez,Craig C Garner,Fabian Fernandez,Craig C Garner,Fabian Fernandez,Craig C Garner,

Developmental intellectual disability (DID) is a daunting societal problem. Although tremendous progress has been made in defining the genetic causes of DID, therapeutic strategies remain limited. In particular, there is a marked absence of a unified approach to treating cognitive impairments associated with DID. Here, we suggest that the brain in many DID-related disorders is subject to a basic imbalance in neuronal activity, with an increased contribution of inhibition to neural circuits. This over-inhibition, in turn, is predicted to lead to deficits in synaptic plasticity and learning and memory. We further discuss possibilities for pharmacological intervention in DID, focusing on the concept of drug-induced 'therapeutic neuroadaptation' as a means of stably enhancing constitutive circuit excitability and cognition over time.

Over-inhibition: a model for developmental intellectual disability. Publishing Authors By Initials

F Fernandez,CC Garner,F Fernandez,CC Garner,F Fernandez,CC Garner,

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Over-inhibition: a model for developmental intellectual disability. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Trends in neurosciences

VOLUME: 30

Page Numbers: 497-503

Journal Abbreviation: Trends Neurosci.

ISSN: 0166-2236

DAY: 6

MONTH: 09

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: Department of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University, 1201 Welch Rd, Palo Alto, CA 94304-5485, USA.

Country: England

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MEDLINETA: Trends Neurosci

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