Over-expression of 14-3-3sigma in budding colorectal cancer cells modulates cell migration in the presence of tenascin-C.

Over-expression of 14-3-3sigma in budding colorectal cancer cells modulates cell migration in the presence of tenascin-C. Research Abstract Details 

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Over-expression of 14-3-3sigma in budding colorectal cancer cells modulates cell migration in the presence of tenascin-C. Abstract Text:

Munenori Ide,Kana Saito,Soichi Tsutsumi,Kaori Tsuboi,Satoru Yamaguchi,Takayuki Asao,Hiroyuki Kuwano,Takashi Nakajima,Munenori Ide,Kana Saito,Soichi Tsutsumi,Kaori Tsuboi,Satoru Yamaguchi,Takayuki Asao,Hiroyuki Kuwano,Takashi Nakajima,Munenori Ide,Kana Saito,Soichi Tsutsumi,Kaori Tsuboi,Satoru Yamaguchi,Takayuki Asao,Hiroyuki Kuwano,Takashi Nakajima,

Epigenetic silencing of the 14-3-3sigma gene by CpG hypermethylation has been reported in many kinds of cancers, but has been considered inapplicable in the colorectal variety. The expression of 14-3-3sigma in colorectal cancer is located primarily in the invasive area. The interaction between tumor cells and the extracellular matrix (ECM) is involved in tumor invasion. In the current study, we investigated the correlation between 14-3-3sigma expression and the ECM, focusing especially on the presence of tenascin-C (TNC) at the invasive area of colorectal cancers. Correlations between the immunohistochemical expression of 14-3-3sigma and TNC, as well as other clinicopathological factors, were evaluated in 123 colorectal carcinoma tissues. 14-3-3sigma expression was frequently observed in budding tumor cells in the invasive area and expression was significantly correlated with budding formation (p=0.001), pTNM classification (p=0.001) and stromal TNC expression (p=0.004). Using colorectal cancer cell lines and ECMs, the up-regulation of 14-3-3sigma mRNA levels was investigated by semi-quantitative RT-PCR. TNC surrounding the tumor cells increased 14-3-3sigma mRNA expression 1.8- to 2.2-fold in HCT116 cells. The effect of 14-3-3sigma over-expression on tumor cell migration was investigated using an agarose-cell droplet migration assay. Over-expression of 14-3-3sigma up-regulated HCT116 cell migration on TNC (p<0.001). We concluded that the expression of 14-3-3sigma in the invasive area modulates tumor cell migration in certain types of colorectal cancer and thus facilitates tumor progression.

Over-expression of 14-3-3sigma in budding colorectal cancer cells modulates cell migration in the presence of tenascin-C. Publishing Authors By Initials

M Ide,K Saito,S Tsutsumi,K Tsuboi,S Yamaguchi,T Asao,H Kuwano,T Nakajima,M Ide,K Saito,S Tsutsumi,K Tsuboi,S Yamaguchi,T Asao,H Kuwano,T Nakajima,M Ide,K Saito,S Tsutsumi,K Tsuboi,S Yamaguchi,T Asao,H Kuwano,T Nakajima,

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Over-expression of 14-3-3sigma in budding colorectal cancer cells modulates cell migration in the presence of tenascin-C. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Oncology reports

VOLUME: 18

Page Numbers: 1451-6

Journal Abbreviation: Oncol. Rep.

ISSN: 1021-335X

DAY: 5

MONTH: Dec

YEAR: 2007

Over-expression of 14-3-3sigma in budding colorectal cancer cells modulates cell migration in the presence of tenascin-C. Information

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LANGUAGE: eng

NlmUniqueID: 9422756

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AFFILIATION: Department of General Surgical Science (Surgery I), Gunma University Graduate School of Medicine, Gunma 371-8511, Japan. muide@showa.gunma-u.ac.jp.

Country: Greece

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MEDLINETA: Oncol Rep

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