Ovariectomized rats show decreased recognition memory and spine density in the hippocampus and prefrontal cortex.

Ovariectomized rats show decreased recognition memory and spine density in the hippocampus and prefrontal cortex. Research Abstract Details 

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Ovariectomized rats show decreased recognition memory and spine density in the hippocampus and prefrontal cortex. Abstract Text:

M Wallace,V Luine,A Arellanos,M Frankfurt,

Effects of ovariectomy (OVX) on performance of the memory tasks, Object Recognition (OR) and Object Placement (OP), and on dendritic spine density in pyramidal neurons in layer II/III of the prefrontal cortex and the CA1 and CA3 regions of the hippocampus were determined. OVX was associated with a significant decline in performance of the memory tasks as compared to intact rats beginning at 1 week post OVX for OR and 4 weeks post OVX for OP. Golgi impregnation at 7 weeks post OVX showed significantly lower spine densities (17-53%) in the pyramidal neurons of the medial prefrontal cortex and the CA1, but not the CA3, region of the hippocampus in OVX compared to intact rats. These results suggest that cognitive impairments observed in OVX rats may be associated with morphological changes in brain areas mediating memory.

Ovariectomized rats show decreased recognition memory and spine density in the hippocampus and prefrontal cortex. Publishing Authors By Initials

M Wallace,V Luine,A Arellanos,M Frankfurt,

For similar nervous system: synapses research abstracts see: nervous system: synapses research

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Ovariectomized rats show decreased recognition memory and spine density in the hippocampus and prefrontal cortex. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Brain research

VOLUME: 1126

Page Numbers: 176-82

Journal Abbreviation: Brain Res.

ISSN: 0006-8993

DAY: 24

MONTH: 08

YEAR: 2006

Ovariectomized rats show decreased recognition memory and spine density in the hippocampus and prefrontal cortex. Information

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LANGUAGE: eng

NlmUniqueID: 45503

Ovariectomized rats show decreased recognition memory and spine density in the hippocampus and prefrontal cortex. Keywords Mesh Terms:

KEYWORDS: Synapses

MESH TERMS: pathology

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Substance Name: Estrogens

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Grant and Affiliation Information for Ovariectomized rats show decreased recognition memory and spine density in the hippocampus and prefrontal cortex.

AFFILIATION: Graduate Center, CUNY, New York, NY 10016, USA. mwallac@hunter.cuny.edu

Country: Netherlands

AGENCY: United States NIGMS

GRANT: S06 GM60654

ACRONYM: GM

MEDLINETA: Brain Res

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