Out-of-hospital coronary heart disease death: acute pathological lesions.

Out-of-hospital coronary heart disease death: acute pathological lesions. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Out-of-hospital coronary heart disease death: acute pathological lesions. Abstract Text:

BACKGROUND: The majority of deaths due to acute coronary heart disease (CHD) occur outside hospital, unexpectedly, within the first few hours following the onset of the terminal event. Data on the incidence and nature of acute pathological findings in the affected hearts as seen in routine autopsies are somewhat controversial. Detailed pathological examination of coronary arteries and myocardium of such decedents was performed to clarify the situation. METHODS AND RESULTS: Full autopsy and detailed macroscopic and microscopic examination of the coronary arteries and myocardium were performed in 170 men, all registered in the Kaunas Acute Myocardial Infarct Register, who died outside hospital of CHD within 6 hours from the onset of symptoms. Out-of-hospital coronary death was in all cases related to acute ischaemic myocardial lesions, either myocardial infarction (MI) in 92.9% of cases or patchy micronecrosis in 7.1%. In the former group, the following stages of acute infarction were found: early MI (hyperacute phase) in 48.8% of cases, definite MI (displaying grossly identifiable coagulative necrosis) in 21.8% and progressing MI (presence of signs of early MI adjacent to a healing infarction) in 22.3%. Signs of new thrombotic coronary events were found in relation to these acute ischaemic myocardial lesions in 88.8% of cases, as occlusive thrombus in 41.2%, non-occlusive, mural thrombus in 37.0% and microthrombi/microemboli in intramyocardial vessels in 10.6%. CONCLUSIONS: Out-of-hospital coronary death most commanly was related to the early or definite stages of myocardial infarction. Accurate identification of these acute ischaemic lesions was based on detailed microscopic examination of the entire ventricular myocardium, with consideration being paid to signs of cardiomyocyte involvement and early inflammatory reaction associated with it. Acute pathology of the affected coronary artery usually confirmed that these myocardial infarct lesions were the cause of the sudden out of-hospital CHD-related deaths.

Out-of-hospital coronary heart disease death: acute pathological lesions. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Out-of-hospital coronary heart disease death: acute pathological lesions. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta cardiologica

VOLUME: 63

Page Numbers: 423-9

Journal Abbreviation:

ISSN: 0001-5385

DAY: 17

MONTH: Aug

YEAR: 2008

Out-of-hospital coronary heart disease death: acute pathological lesions. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370570

Out-of-hospital coronary heart disease death: acute pathological lesions. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Out-of-hospital coronary heart disease death: acute pathological lesions. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Out-of-hospital coronary heart disease death: acute pathological lesions.

AFFILIATION: Laboratory of Cardiac Pathology, Institute of Cardiology, Kaunas University of Medicine, Kaunas, Lithuania.

Country: Belgium

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Acta Cardiol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Out-of-hospital coronary heart disease death: acute pathological lesions Related Publications

• Clinical relevance of discography combined with CT scanning. A study of 100 patients.
• Correction of chronic lunotriquetral instability using extensor retinacular split: a retrospective study of 26 patients.
• Differential expression of Toll-like receptors in chronic hyperplastic candidosis.
• Effect of physical activity on postprandial levels of fats in serum.
• Hepatotoxicity of sulphamethoxyridazine.
• Imbalance of RANKL/RANK/OPG system in interface tissue in loosening of total hip replacement.
• Immunohistochemical localization of Toll-like receptors 1-10 in periodontitis.
• Neuroelectrostimulation in Treatment of Hyposalivation and Xerostomia in Sjögren's Syndrome: A Salivary Pacemaker.
• New operative technique for treatment of arthroscopically-confirmed injury to the scapholunate ligament by volar capsuloplasty augmented with a free tendon graft.
• Out-of-hospital coronary heart disease death: acute pathological lesions.
• Regression of heterotopic ossification after starting warfarin -- an effect mediated by inhibition of gamma-carboxylation of osteocalcin? -- a case report.
• Special modes of corrosion under physiological and simulated physiological conditions.
• The protein kinase C system in focal adenitis of the lacrimal gland in the non-obese diabetic mouse model for Sjögren's syndrome.
• Type IV collagen alpha-chain composition in synovial lining from trauma patients and patients with rheumatoid arthritis.