[Osteoblasts derived from mesenchymal stem cells harbor immunoregulatory effect]

[Osteoblasts derived from mesenchymal stem cells harbor immunoregulatory effect] Research Abstract Details 

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[Osteoblasts derived from mesenchymal stem cells harbor immunoregulatory effect] Abstract Text:

Xiao-Xia Jiang,Yi Zhang,Xiu-Sen Li,Ying Wu,Xiao-Dan Yu,Pei-Hsien Tang,Ning Mao,

In an attempt to study the immunoregulatory effect of osteoblasts derived from mesenchymal stem cells (MSC), MSC was induced to differentiate into osteoblasts for one week. The growth pattern and the phenotype were evaluated by MTT and flow cytometry respectively. The immunoregulatory effect was tested by the inhibitory effect on T cell proliferation. The result showed that during the differentiation cells grew fast and there was no significant change in the phenotypes but keeping CD73, CD105, CD44, CD29 positive and CD34, CD45, HLA-DR, CD86 negative. Osteocyte derived from MSC also showed immunosuppressive effect on T cell proliferation in adose-dependent manner. It is concluded that osteoblasts derived from MSC also harbored immunoregulatory effect.

[Osteoblasts derived from mesenchymal stem cells harbor immunoregulatory effect] Publishing Authors By Initials

XX Jiang,Y Zhang,XS Li,Y Wu,XD Yu,PH Tang,N Mao,

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[Osteoblasts derived from mesenchymal stem cells harbor immunoregulatory effect] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhongguo shi yan xue ye xue za zhi / Zhongguo bing

VOLUME: 13

Page Numbers: 50-3

Journal Abbreviation: Zhongguo Shi Yan Xue Ye Xue Za

ISSN: 1009-2137

DAY: 7

MONTH: Feb

YEAR: 2005

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LANGUAGE: chi

NlmUniqueID: 101084424

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AFFILIATION: Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850, China.

Country: China

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MEDLINETA: Zhongguo Shi Yan Xue Ye Xue Za

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