Oskar controls morphology of polar granules and nuclear bodies in Drosophila.

Oskar controls morphology of polar granules and nuclear bodies in Drosophila. Research Abstract Details 

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Oskar controls morphology of polar granules and nuclear bodies in Drosophila. Abstract Text:

Jennifer R Jones,Paul M Macdonald,

Germ cell formation in Drosophila relies on polar granules, which are large ribonucleoprotein complexes found at the posterior end of the embryo. The granules undergo characteristic changes in morphology during development, including the assembly of multiple spherical bodies from smaller precursors. Several polar granule components, both protein and RNA, have been identified. One of these, the protein Oskar, acts to initiate granule formation during oogenesis and to recruit other granule components. To investigate whether Oskar has a continuing role in organization of the granules and control of their morphology, we took advantage of species-specific differences in polar granule structure. The polar granules of D. immigrans fuse into a single large oblong aggregate, as opposed to the multiple, distinct, spherical granules of D. melanogaster embryos. D. immigrans oskar rescues the body patterning and pole cell defects of embryos from D. melanogaster oskar(-) mothers, and converts the morphology of the polar granules to that of D. immigrans. The nuclear bodies, which are structures that appear to be closely related to polar granules, are also converted to the D. immigrans type morphology. We conclude that oskar plays a persistent and central role in the polar granules, not only initiating their formation but also controlling their organization and morphology.

Oskar controls morphology of polar granules and nuclear bodies in Drosophila. Publishing Authors By Initials

JR Jones,PM Macdonald,

For similar urogenital system: genitalia: germ cells: ovum: oocytes research abstracts see: urogenital system: genitalia: germ cells: ovum: oocytes research

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MEDLINE DATE:

Oskar controls morphology of polar granules and nuclear bodies in Drosophila. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Development (Cambridge, England)

VOLUME: 134

Page Numbers: 233-6

Journal Abbreviation: Development

ISSN: 0950-1991

DAY: 6

MONTH: 12

YEAR: 2006

Oskar controls morphology of polar granules and nuclear bodies in Drosophila. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8701744

Oskar controls morphology of polar granules and nuclear bodies in Drosophila. Keywords Mesh Terms:

KEYWORDS: Oocytes

MESH TERMS: metabolism

Chemical & Substance for Abstract: Oskar controls morphology of polar granules and nuclear bodies in Drosophila. Information

Substance Name: oskar protein, Drosophila

Registry Number: 0

Grant and Affiliation Information for Oskar controls morphology of polar granules and nuclear bodies in Drosophila.

AFFILIATION: Institute for Cellular and Molecular Biology, Section of Molecular Cell and Developmental Biology, The University of Texas at Austin, Austin, TX 78712-0159, USA.

Country: England

AGENCY: United States NIGMS

GRANT: GM54409

ACRONYM: GM

MEDLINETA: Development

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