Orphan nuclear receptor function in the ovary.

Orphan nuclear receptor function in the ovary. Research Abstract Details 

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Orphan nuclear receptor function in the ovary. Abstract Text:

Huajun Zhao,Zili Li,Austin J Cooney,Zi-Jian Lan,

Orphan nuclear receptors such as germ cell nuclear factor (GCNF), steroidogenic factor 1 (SF-1) and liver receptor homolog-1 (LRH-1), are emerging as important ovarian factors in regulating female reproduction. Within the ovary, GCNF (NR6A1) expression is restricted to the oocyte, while SF-1 (NR5A1) is expressed only in the somatic cells, such as granulosa, thecal and luteal cells, and interstitial cells. LRH-1 (NR5A2), an orphan receptor closely related to SF-1, is expressed only in the granulosa cells of the follicles and luteal cells within the ovary. Recent studies using conditional knockout strategies to bypass the embryonic lethality of GCNF and SF-1 null mice have uncovered important roles of GCNF and SF-1 in the oocyte and granulosa cells, respectively. In this review, we will summarize the major findings of GCNF and SF-1 in the ovary from the studies of conditional GCNF and SF-1 knockout mice. The potential role of LRH-1 in the ovary is also briefly discussed. Understanding the ovarian functions of these orphan nuclear receptors may lead to the development of new agents for regulation of female fertility and new medicines for the treatment of female idiopathic infertility, premature ovarian failure, polycystic ovarian syndrome and ovarian cancer.

Orphan nuclear receptor function in the ovary. Publishing Authors By Initials

H Zhao,Z Li,AJ Cooney,ZJ Lan,

For similar urogenital system: genitalia: genitalia, female: adnexa uteri: ovary research abstracts see: urogenital system: genitalia: genitalia, female: adnexa uteri: ovary research

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Orphan nuclear receptor function in the ovary. Journal Published:

PUBLICATION TYPE: Review

Journal: Frontiers in bioscience : a journal and virtual li

VOLUME: 12

Page Numbers: 3398-405

Journal Abbreviation: Front. Biosci.

ISSN: 1093-4715

DAY: 1

MONTH: 05

YEAR: 2007

Orphan nuclear receptor function in the ovary. Information

Number of References: 97

LANGUAGE: eng

NlmUniqueID: 9709506

Orphan nuclear receptor function in the ovary. Keywords Mesh Terms:

KEYWORDS: Ovary

MESH TERMS: metabolism

Chemical & Substance for Abstract: Orphan nuclear receptor function in the ovary. Information

Substance Name: Nuclear Proteins

Registry Number: 0

Grant and Affiliation Information for Orphan nuclear receptor function in the ovary.

AFFILIATION: Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, University of Louisville Health Sciences Center, Louisville, KY 40202, USA.

Country: United States

AGENCY: United States NIDCR

GRANT: P20-RR/DE177702

ACRONYM: DE

MEDLINETA: Front Biosci

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